Rhythm on a chip: circadian entrainment in vitro is the next frontier in body-on-a chip technology
Rhythm on a chip: circadian entrainment in vitro is the next frontier in body-on-a chip technology
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DOI：
10.1016/j.coph.2019.09.005
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发表时间：
2019-10-01
影响因子：
4
通讯作者：
Stewart, Alastair G.
中科院分区：
文献类型：
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作者：
Fustin, Jean-Michel;Li, Meina;Stewart, Alastair G.
类器官、生物打印微型组织和人体芯片技术有望改变临床前药理学的实践，以期实现更好的预测价值。我们回顾了在这种微环境的静态和动态生物力学方面进一步完善的需要。进一步考虑灌注系统所需的发展，以提供适当的可溶性微环境。我们特别强调了这些系统的一个主要缺陷，即在这种环境中使用的细胞缺乏或异常的昼夜节律行为，并考虑了为了实现芯片上的节奏需要满足的技术挑战。
Organoids, bioprinted mini-tissues and body-on-a-chip technologies are poised to transform the practice of preclinical pharmacology, with a view to achieving better predictive value. We review the need for further refinement in static and dynamic biomechanical aspects of such microenvironments. Further consideration of the developments required in perfusion systems to enable delivery of an appropriate soluble microenvironment are argued. We place particular emphasis on a major deficiency in these systems, being the absence or aberrant circadian behaviour of cells used in such settings, and consider the technical challenges that are needing to be met in order to achieve rhythm-on-a-chip.