NEW INSIGHTS INTO PROTEASOME FUNCTION - FROM ARCHAEBACTERIA TO DRUG DEVELOPMENT
NEW INSIGHTS INTO PROTEASOME FUNCTION - FROM ARCHAEBACTERIA TO DRUG DEVELOPMENT
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DOI：
10.1016/1074-5521(95)90182-5
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发表时间：
1995-08-01
影响因子：
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通讯作者：
GOLDBERG, AL
中科院分区：
文献类型：
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作者：
GOLDBERG, AL
蛋白酶体不仅仅是一个“垃圾处理单元”，还具有控制细胞周期和免疫反应的功能。最近，古细菌蛋白酶体的结构已被确定为高分辨率，并提供了对蛋白酶体蛋白水解切割的不寻常机制的深入了解。
The proteasome is not simply a 'garbage disposal unit' but also has functions in the control of the cell cycle and immune responses. The structure of an archaebacterial proteasome has recently been determined to high resolution, and provides insight into the unusual mechanism of proteolytic cleavage by the proteasome.