No consistent difference in gray matter volume between individuals with fibromyalgia and age-matched healthy subjects when controlling for affective disorder.
No consistent difference in gray matter volume between individuals with fibromyalgia and age-matched healthy subjects when controlling for affective disorder.
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控制情感障碍时，纤维肌痛和年龄匹配的健康受试者之间的灰质体积没有一致的差异。
DOI：
10.1016/j.pain.2009.03.017
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发表时间：
2009-06
期刊：
影响因子：
7.4
通讯作者：
Williams DA
中科院分区：
文献类型：
--
作者：
Hsu MC;Harris RE;Sundgren PC;Welsh RC;Fernandes CR;Clauw DJ;Williams DA
纤维肌痛（FM）被认为涉及中枢疼痛处理的异常。最近涉及小样本的研究表明，FM患者大脑中的灰质体积（GMV）发生了变化。我们的目标是在控制情感性障碍（AD）存在的情况下，使用基于体素的形态测定法（VBM）在更大的样本中验证这些发现。使用3T扫描仪对29例伴有AD的FM患者、29例无AD的FM患者和29例年龄匹配的健康对照（HC）进行t1加权磁共振成像（MRI）脑部扫描。使用SPM5中的自动协议执行分割、空间规范化和体积调制。将平滑的灰质片段输入到体素方向的单向方差分析中，并使用先前研究中发表的阈值方法搜索显著聚类（全脑阈值p< 0.05校正多重比较；兴趣区域（ROI）阈值p≤0.001未校正，或p< 0.05小体积校正）。全脑分析没有发现任何显著的集群。基于roi的分析显示，三组患者左前岛叶GMV有显著差异（xyz={−28,21,9};p= 0.026，校正后）。然而，在事后测试中，从该聚类中提取的平均GMV，没有AD的FM患者与HC患者没有显著差异。平均聚类GMV与特质焦虑得分呈显著负相关（状态-特质人格量表，特质焦虑量表；rho=−）。470年,p <措施)。在基于roi的分析中未发现其他显著聚类。我们的研究结果强调了在进行慢性疼痛的VBM研究时纠正AD的重要性。
Fibromyalgia (FM) is thought to involve abnormalities in central pain processing. Recent studies involving small samples have suggested alterations in gray matter volume (GMV) in brains of FM patients. Our objective was to verify these findings in a somewhat larger sample using voxel-based morphometry (VBM), while controlling for presence of affective disorders (AD). T1-weighted magnetic resonance image (MRI) brain scans were obtained on 29 FM patients with AD, 29 FM patients without AD, and 29 age-matched healthy controls (HC) using a 3T scanner. Segmentation, spatial normalization, and volumetric modulation were performed using an automated protocol within SPM5. Smoothed gray matter segments were entered into a voxel-wise one-way ANOVA, and a search for significant clusters was performed using thresholding methods published in previous studies (whole-brain threshold of p<.05 correcting for multiple comparisons; region-of-interest (ROI) threshold of p≤.001 uncorrected, or p<.05 small-volume corrected). The whole-brain analysis did not reveal any significant clusters. ROI-based analysis revealed a significant difference in left anterior insula GMV among the three groups (xyz={−28, 21, 9}; p=.026, corrected). However, on post-hoc testing, FM patients without AD did not differ significantly from HC with respect to mean GMV extracted from this cluster. A significant negative correlation was found between mean cluster GMV and scores of trait anxiety (State-Trait Personality Inventory, Trait Anxiety scale; rho=−.470, p<.001). No other significant clusters were found on ROI-based analysis. Our results emphasize the importance of correcting for AD when carrying out VBM studies in chronic pain.
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影响因子：
7.4
作者：
Schmidt-Wilcke, T.;Luerding, R.;Bogdahn, U.
通讯作者：
Bogdahn, U.
影响因子：
--
作者：
Harris, RE;Williams, DA;Clauw, DJ
通讯作者：
Clauw, DJ
影响因子：
5.3
作者：
Kuchinad, Anil;Schweinhardt, Petra;Bushnell, M. Catherine
通讯作者：
Bushnell, M. Catherine
影响因子：
5.3
作者：
Sheehan, DV;Lecrubier, Y;Dunbar, GC
通讯作者：
Dunbar, GC
影响因子：
5.3
作者：
Apkarian, AV;Sosa, Y;Gitelman, DR
通讯作者：
Gitelman, DR