Electrodermal activity in schizophrenia: A quantitative study using a short interstimulus paradigm
Electrodermal activity in schizophrenia: A quantitative study using a short interstimulus paradigm
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DOI：
10.1016/s0006-3223(98)00056-0
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发表时间：
1999-01-01
影响因子：
10.6
通讯作者：
Rennie, C
中科院分区：
文献类型：
--
作者：
Lim, CL;Gordon, E;Rennie, C
背景资料：响应于短刺激间隔（ISI）刺激的皮电活动允许检查信息处理的各个方面，但是这样的范例导致皮肤电导响应（SCR）重叠。开发了一种信号分解方法，并用于对重叠的SCR进行评分。方法：采用常规的听觉oddball范式，ISI为1.3秒，对30例精神分裂症患者和50例正常对照者的皮肤电活动进行了研究。结果：精神分裂症组的反应率、反应者比例、SCR波幅、上升时间、峰值潜伏期和稳态反应波幅均低于对照组，而对照组的反应率、反应者比例、SCR波幅、上升时间、峰值潜伏期和稳态反应波幅均低于对照组。有SCL或SCR onset time.Conclusions组间差异：传统的短ISI范式和新的SCP吓唬方法的结合使用表现出新的方面的皮肤电低反应性在药物治疗的精神分裂症患者。低反应性不能归因于紧张性唤醒的变化或外周交感神经传导功能障碍。生物精神病学1999;45：127-135（C）1999年生物精神病学学会。
Background: Electrodermal activity in response to short interstimulus interval (ISI) stimulation allows aspects of information processing to be examined, but such paradigms cause skin conductance responses (SCRs) to overlap. A signal decomposition method was developed and employed to score the overlapped SCRs. This is the first application of the method to the study of schizophrenia.Methods: Electrodermal activity of 30 medicated patients with schizophrenia and 50 normal controls was obtained using a conventional auditory oddball paradigm with an ISI of 1.3 sec. Tonic skin conductance level (SCL), phasic SCRs, SCR temporal dynamics, and a range of SCR variables in response to target tones were examinedResults: The schizophrenic group showed reduced response rate, proportion of responders, SCR amplitude, rise time, peak latency, and steady-state response amplitude over the trial compared with controls. There were no between-group differences in SCL or SCR onset time.Conclusions: The combined use of a conventional short ISI paradigm and the new SCP scaring method demonstrated new facets of electrodermal hyporeactivity in medicated patients with schizophrenia. The hyporeactivity could not be attributed to changes in tonic arousal or dysfunctions in peripheral sympathetic nerve conductance. Biol Psychiatry 1999;45:127-135 (C) 1999 Society of Biological Psychiatry.