Association of autoantibodies to myeloperoxidase with different forms of vasculitis.
Association of autoantibodies to myeloperoxidase with different forms of vasculitis.
复制标题
髓过氧化物酶自身抗体与不同形式的血管炎的关联。
DOI：
10.1002/art.1780330829
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发表时间：
2010
影响因子：
--
通讯作者：
C. Kallenberg
中科院分区：
文献类型：
--
作者：
J. Tervaert;R. Goldschmeding;J. Elema;P. Limburg;M. Giessen;M. Huitema;M. Koolen;R. Hené;G. Hem;A. Borne;C. Kallenberg
在常规提交抗中性粒细胞胞浆抗体检测的53例患者血清中发现抗中性粒细胞胞浆抗体。根据临床和组织学标准，53例患者中15例为多动脉炎组的全身性坏死性血管炎，11例为韦格纳肉芽肿(WG)，14例为特发性新月体肾炎。其余13名患者不符合这些疾病的诊断标准，尽管大多数患者的临床症状与这些疾病相匹配。虽然所有WG患者都有肾脏损害，但在多动脉炎组的15例系统性坏死性血管炎患者中，只有4例有肾小球肾炎。我们对所有患有这些疾病的患者(n=104)进一步测试了MPO自身抗体对多发性动脉炎组的全身性坏死性血管炎或特发性新月体肾炎的敏感性。104名患者中有27名患者有MPO自身抗体。此外，在剩下的77名患者中，有69名患者具有29kd丝氨酸蛋白酶的自身抗体，据报道，该酶与WG特异性相关。8例患者血清这两种抗体均为阴性(自身抗体对MPO和/或29kd丝氨酸蛋白酶的敏感性为92%)。抗MPO自身抗体对多发性动脉炎组的全身性坏死性血管炎或特发性新月体肾炎的特异性也在选定的有密切相关疾病的患者组中进行了测试。144例患者中有2例有MPO自身抗体(特异度为99%)。
Antineutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase (MPO) were found in 53 patient sera that were routinely submitted for antineutrophil cytoplasmic antibody determination. Based on clinical and histologic criteria, 15 of these 53 patients were classified as having systemic necrotizing vasculitis of the polyarteritis group, 11 patients were classified as having Wegener's granulomatosis (WG), and 14 were classified as having idiopathic crescentic glomerulonephritis. The remaining 13 patients did not fulfill the diagnostic criteria for these disorders, although most of these patients had clinical symptoms compatible with these disorders. While all patients with WG had renal involvement, only 4 of the 15 patients with systemic necrotizing vasculitis of the polyarteritis group had glomerulonephritis. The sensitivity of autoantibodies to MPO for either systemic necrotizing vasculitis of the polyarteritis group, WG, or idiopathic crescentic glomerulonephritis was further tested in all our patients with these disorders (n = 104). Twenty-seven of 104 patients had autoantibodies to MPO. Furthermore, 69 of the remaining 77 patients had autoantibodies specific for the 29-kd serine protease, which has been reported to be specifically associated with WG. Sera from 8 patients were negative for either of these antibodies (92% sensitivity of autoantibodies to MPO and/or the 29-kd serine protease). The specificity of autoantibodies to MPO for either systemic necrotizing vasculitis of the polyarteritis group, WG, or idiopathic crescentic glomerulonephritis was also tested in selected groups of patients who had closely related diseases. Two of 144 patients had autoantibodies to MPO (specificity 99%).(ABSTRACT TRUNCATED AT 250 WORDS)
影响因子：
158.5
作者：
FALK, RJ;JENNETTE, JC
通讯作者：
JENNETTE, JC