Functional properties of single neurons in the primate face primary somatosensory cortex. I. Relations with trained orofacial motor behaviors.
Functional properties of single neurons in the primate face primary somatosensory cortex. I. Relations with trained orofacial motor behaviors.
复制标题
灵长类动物面部初级体感皮层单个神经元的功能特性。
作者：
Li;G. M. Murray;B. Sessle
1.我们最近已经证明，可逆的，冷却诱导的面部初级体感皮层（SI）的失活严重损害了舌头伸出任务的成功执行，但对咬任务的性能有相对较小的影响。在试图建立一个神经元相关的这些不同的行为关系，本研究开始记录人口的面SI神经元的机械感受野特性和他们的活动在舌头伸出和咬任务。2.在SI内，面部的表征被发现直接位于手的表征的外侧，并且在面部SI内有一个明确的组织的躯体位置模式：眶周或鼻区域位于面部SI的最内侧，然后依次在外侧依次是上唇、下唇和口内区域的表征。一个机械感受野（RF）被确定为253个神经元，其中包括162个“唇RF”神经元接收来自上唇，下唇，或两者的机械敏感传入输入; 72个“舌RF”神经元接收来自舌头的机械敏感传入输入; 11个“牙周RF”神经元接收牙周输入;和8个神经元接收来自其他orofacial区域的输入。3.几乎所有（249/253）的面SI神经元对轻触觉刺激有反应，其中大多数接受对侧输入（78%），并对触觉刺激表现出快速适应（RA）反应（82%）。3b区和1区的慢适应神经元与RA神经元的比例无显著差异。4.在一个或两个orofacial任务中研究的193个神经元中，113个被发现，在组织学重建的基础上，分布在1区，61个在3b区，19个在2区。5.大多数舌RF（79%的56）神经元和唇RF（60%的93）神经元测试的放电率显着改变舌头伸出任务。只有一些（14%的36个舌RF神经元和34%的92唇RF神经元测试）显示出显着的变化，在咬任务的放电率。在舌头伸出任务中研究的7个牙周膜RF神经元中有3个改变了它们的发射率，10个中有5个在咬任务中改变了它们的发射率。6.大多数的116面SI神经元在这两个任务的研究表现出优先关系的舌头突出任务，不同的咬任务，没有显示任务相关的活动，在咬任务。（400字处截断摘要）
1. We have demonstrated recently that reversible, cooling-induced inactivation of the face primary somatosensory cortex (SI) severely impairs the successful performance of a tongue-protrusion task but has relatively minor effects on the performance of a biting task. In an attempt to establish a neuronal correlate for these different behavioral relations, the present study was initiated to document the mechanoreceptive field properties of a population of face SI neurons and their activity during the tongue-protrusion and biting tasks. 2. Within SI, the representation of the face was found immediately lateral to that of the hand, and there was a clear somatotopic pattern of organization within face SI: the periorbital or nose region was located most medially in the face SI, then followed laterally in sequence the representation of the upper lip, lower lip, and intraoral area. A mechanoreceptive field (RF) was identified for 253 neurons, which included 162 "lip RF" neurons receiving mechanosensitive afferent inputs from the upper lip, lower lip, or both; 72 "tongue RF" neurons that received mechanosensitive afferent inputs from the tongue; 11 "periodontium RF" neurons receiving periodontal inputs; and 8 neurons that received inputs from other orofacial regions. 3. Nearly all (249/253) of the face SI neurons responded to light tactile stimuli, and most of them received contralateral inputs (78%) and showed a rapidly adapting (RA) response to tactile stimulation (82%). There was no significant difference in the ratio of slowly adapting (SA) to RA neurons in areas 3b and 1. 4. For 193 neurons studied in one or both of the orofacial tasks, 113 were found, on the basis of histological reconstruction, to be distributed in area 1, 61 in area 3b, and 19 in area 2. 5. The firing rate of most tongue RF (79% of 56) neurons and lip RF (60% of 93) neurons tested was significantly altered during the tongue-protrusion task. Only some (14% of 36 tongue RF neurons and 34% of the 92 lip RF neurons tested) showed a significant change in firing rate during the biting task. Three of 7 periodontium RF neurons studied in the tongue-protrusion task altered their firing rate and 5 of 10 altered their firing rate during the biting task. 6. Most of the 116 face SI neurons studied during both tasks exhibited a preferential relation to the tongue-protrusion task as distinct from the biting task, and none showed task-related activity during the biting task only.(ABSTRACT TRUNCATED AT 400 WORDS)