The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin
The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin
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DOI：
10.1038/ni.2744
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发表时间：
2013-12-01
影响因子：
30.5
通讯作者：
Gebhardt, Thomas
中科院分区：
文献类型：
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作者：
Mackay, Laura K.;Rahimpour, Azad;Gebhardt, Thomas
组织驻留记忆T细胞（TRM细胞）在淋巴外组织中提供对抗感染的上级保护。在这里，我们发现，CD 103（+）CD 8（+）TRM细胞在皮肤中从上皮浸润的前体细胞发展而来，这些前体细胞缺乏效应细胞标志物KLRG 1的表达。这些长寿记忆细胞的形成需要进入上皮细胞加上白细胞介素15（IL-15）和转化生长因子-β（TGF-β）的局部信号传导的组合。值得注意的是，分化成TRM细胞导致了独特的转录谱的逐步获得，该转录谱不同于循环记忆细胞和永久驻留在皮肤上皮中的其他类型的T细胞。我们提供了一个全面的分子框架，局部分化的一个独特的外周人口的记忆细胞，形成了一线免疫防御系统的屏障组织。
Tissue-resident memory T cells (TRM cells) provide superior protection against infection in extralymphoid tissues. Here we found that CD103(+)CD8(+) TRM cells developed in the skin from epithelium-infiltrating precursor cells that lacked expression of the effector-cell marker KLRG1. A combination of entry into the epithelium plus local signaling by interleukin 15 (IL-15) and transforming growth factor-beta (TGF-beta) was required for the formation of these long-lived memory cells. Notably, differentiation into TRM cells resulted in the progressive acquisition of a unique transcriptional profile that differed from that of circulating memory cells and other types of T cells that permanently reside in skin epithelium. We provide a comprehensive molecular framework for the local differentiation of a distinct peripheral population of memory cells that forms a first-line immunological defense system in barrier tissues.