CHRONIC WASTING DISEASE OF CAPTIVE MULE DEER - SPONGIFORM ENCEPHALOPATHY
CHRONIC WASTING DISEASE OF CAPTIVE MULE DEER - SPONGIFORM ENCEPHALOPATHY
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DOI：
10.7589/0090-3558-16.1.89
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发表时间：
1980-01-01
影响因子：
1.3
通讯作者：
YOUNG, S
中科院分区：
文献类型：
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作者：
WILLIAMS, ES;YOUNG, S
在过去的12年中(1967-1979)，在美国科罗拉多州和怀俄明州的几个野生动物设施中，圈养了53头黑尾鹿和1头黑尾鹿，发现了一种被鉴定为慢性消耗性疾病的综合征。成年鹿出现临床症状，包括行为改变、体重进行性下降和在2周至8个月内死亡。大体解剖发现包括消瘦和过多的瘤胃液混合沙子和砾石。一致的组织病理学改变局限于中枢神经系统，其特征是广泛的神经纤维海绵状转化，神经元核周的单个或多个胞浆内空泡，以及强烈的星形细胞肥大和增生。介绍了慢性消耗性疾病的临床特征，并支持了这种疾病是一种特殊的自发性脑病的事实。
In the past 12 yr (1967-1979) a syndrome identified as chronic wasting disease was observed in 53 mule deer (Odocoileus hemionus hemionus) and 1 black-tailed deer (O. hemionus columbianus) held in captivity in several wildlife facilities in Colorado, USA and more recently in Wyoming, USA. Clinical signs were seen in adult deer and included behavioral alterations, progressive weight loss and death in 2 wk to 8 mo. Gross necropsy findings included emaciation and excess rumen fluid admixed with sand and gravel. Consistent histopathologic change was limited to the CNS and characterized by widespread spongiform transformation of the neuropil, single or multiple intracytoplasmic vacuoles in neuronal perikaryons and intense astrocytic hypertrophy and hyperplasia. A clinical characterization of chronic wasting disease is presented and the fact that the disease is a specific spontaneously occurring form of spongiform encephalopathy is supported.