Association of genetic polymorphisms in IL-23R and IL-17A with the susceptibility to IgA nephropathy in a Chinese Han population
Association of genetic polymorphisms in IL-23R and IL-17A with the susceptibility to IgA nephropathy in a Chinese Han population
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IL-23R和IL-17A基因多态性与中国汉族人群IgA肾病易感性的关系
DOI：
10.1038/s41435-021-00160-6
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发表时间：
2021-12-24
影响因子：
5
通讯作者：
Yang，Bin
中科院分区：
文献类型：
--
作者：
Liao，Hongyan;Huang，Zhuochun;Yang，Bin
伊加肾病（IgAN）是全球慢性肾损伤的最常见原因之一。识别与IgAN风险相关的新遗传因素具有非常重要的意义。为探讨IL-23 R和IL-17 A基因多态性与IgA肾病易感性的关系，对164例IgA肾病患者和192例健康对照者进行了5个SNPs的基因分型。同时对IgAN患者的基因型分布、临床指标和病理分级进行比较分析。与TT基因型和T等位基因相比，rs7517847的GG基因型和G等位基因分别与IgAN风险降低相关（OR：0.545; 95%CI：0.299-0.993;p= 0.046; OR：0.730; 95%CI：0.541-0.984;p= 0.039）。此外，与GG基因型相比，rs 2275913的AA基因型似乎降低了IgAN的风险（OR：0.405; 95%CI：0.209-0.786;p= 0.007）。在隐性遗传模型下，AA基因型个体的IgA肾病风险较低（OR：0.380; 95%CI：0.211-0.686;p= 0.001）。我们的研究首次证实了IL-23 R中rs7517847和IL-17 A中rs 2275913与中国汉族IgAN的风险显著相关。
IgA Nephropathy (IgAN) is one of the most common causes of chronic kidney damage worldwide. Identifying new genetic factors associated with IgAN risk is of invaluable importance. To explore the association between polymorphisms of IL-23R and IL-17A and the susceptibility of IgAN, 164 IgAN patients and 192 healthy controls were genotyped for five SNPs in a Chinese Han population. A comparative analysis between genotype distributions, clinical indexes and pathological grades in the IgAN patients was also performed. The GG genotype and a G allele of rs7517847 were associated with a decreased IgAN risk (OR: 0.545; 95% CI: 0.299–0.993;p= 0.046; OR: 0.730; 95% CI: 0.541–0.984;p= 0.039) compared to the TT genotype and T allele respectively. Furthermore, the AA genotype of rs2275913 appeared to reduce the IgAN risk (OR: 0.405; 95% CI: 0.209–0.786;p= 0.007) compared to the GG genotype. Consistently, individuals harboring an AA genotype had a lower IgAN risk (OR: 0.380; 95% CI: 0.211–0.686;p= 0.001) under the recessive model. Our study demonstrated for the first time the significant associations of rs7517847 in IL-23R and rs2275913 in IL-17A with the risk of IgAN in Chinese Han.