Clinical Characteristics and Predictors of Outcome for Onconeural Antibody-Associated Disorders: A Retrospective Analysis.
Clinical Characteristics and Predictors of Outcome for Onconeural Antibody-Associated Disorders: A Retrospective Analysis.
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肿瘤神经抗体相关疾病的临床特征和结果预测：回顾性分析
DOI：
10.3389/fneur.2017.00584
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发表时间：
2017
影响因子：
3.4
通讯作者：
Cao B
中科院分区：
文献类型：
--
作者：
Liao S;Qian Y;Hu H;Niu B;Guo H;Wang X;Miao S;Li C;Cao B
描述和分析肿瘤神经抗体相关疾病（OAAD）患者的临床特征、实验室数据、管理和预后，并确定不良预后的预测因素。本研究对2009年9月至2017年7月在济南市总医院住院的所有潜在OAAD患者进行回顾性分析。我们明确了诊断，收集了全面的信息，并将患者分为三组：副肿瘤神经系统疾病（PNDs）、自身免疫性脑炎（AE）和可能的OAAD。在这三组中，我们分析了一系列临床和实验室参数，并使用单变量和多变量回归分析来确定不良预后的预测因素[改良Rankin量表(mRS) = 3-6]。从158例患者中，我们确定了70例符合OAAD标准的患者，其中男性44例（62.9%），女性26例（37.1%）。PNDs组38例（54.3%），AE组14例（20%），OAAD可能组18例（25.7%）。末次随访后，14例（36.8%）、9例（64.2%）、12例（66.7%）预后良好（mRS = 0 ~ 2）。死亡6例（15.8%），2例（14.3%），3例（16.7%）。单因素分析显示，住院时间（p = 0.0224）和尿失禁/尿潴留（p = 0.0043）与预后不良相关（mRS = 3-6）。多因素回归分析显示，尿失禁/尿潴留（p = 0.0388）和免疫功能低下（p = 0.0247）仍然是不良预后的重要因素。尿失禁/尿潴留和免疫功能低下状态是OAAD患者预后较差的重要预测因素。相比之下，脑脊液分析显示血清自身抗体和肿瘤标志物、关键器官功能、电生理和放射学检查结果与预后不良无关。
To describe and analyze the clinical characteristics, laboratory data, management, and outcome of patients with onconeural antibody-associated disorders (OAAD) and identify predictors for poor outcome. This was a retrospective review of all patients with potential OAAD, who were hospitalized in Jinan General Hospital between September 2009 and July 2017. We clarified the diagnosis, collected comprehensive information and categorized patients into three groups: paraneoplastic neurological disorders (PNDs), autoimmune encephalitis (AE), and possible OAAD. Within the three groups, we analyzed a range of clinical and laboratory parameters and used univariate and multivariate regression analysis to identify predictors for poor outcome [modified Rankin Scale (mRS) = 3–6]. From 158 patients, we identified 70 who fulfilled the criteria for OAAD, including 44 men (62.9%) and 26 women (37.1%). There were 38 patients (54.3%) in the PNDs group, 14 patients (20%) in the AE group, and 18 patients (25.7%) in the possible OAAD group. After the last follow-up, 14 (36.8%), 9 (64.2%), and 12 (66.7%) had a good outcome (mRS = 0–2). However, 6 (15.8%), 2 (14.3%), and 3 (16.7%) died, respectively. Univariate analysis showed that duration prior to the hospital (p = 0.0224) and urinary incontinence/retention (p = 0.0043) were associated with poor outcome (mRS = 3–6). After multivariate regression analysis, urinary incontinence/retention (p = 0.0388) and an immunocompromised state (p = 0.0247) remained as significant factors for poor outcome. Urinary incontinence/retention and an immunocompromised state represent significant predictors of a worse prognosis for patients with OAAD. By contrast, cerebrospinal fluid analysis showed that serum autoantibodies and tumor markers, the function of crucial organs, electrophysiology, and radiological findings were not associated with a poor outcome.
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DOI：
10.1093/brain/awq113
发表时间：
2010-06
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Irani SR;Bera K;Waters P;Zuliani L;Maxwell S;Zandi MS;Friese MA;Galea I;Kullmann DM;Beeson D;Lang B;Bien CG;Vincent A
通讯作者：
Vincent A
DOI：
10.1016/j.jpeds.2012.10.011
发表时间：
2013-04
期刊：
The Journal of pediatrics
影响因子：
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作者：
Armangue T;Titulaer MJ;Málaga I;Bataller L;Gabilondo I;Graus F;Dalmau J;Spanish Anti-N-methyl-D-Aspartate Receptor (NMDAR) Encephalitis Work Group
通讯作者：
Spanish Anti-N-methyl-D-Aspartate Receptor (NMDAR) Encephalitis Work Group
影响因子：
56.3
作者：
Granerod, Julia;Ambrose, Helen E.;Crowcroft, Natasha S.
通讯作者：
Crowcroft, Natasha S.
DOI：
10.1016/s1474-4422(15)00401-9
发表时间：
2016-04
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Graus F;Titulaer MJ;Balu R;Benseler S;Bien CG;Cellucci T;Cortese I;Dale RC;Gelfand JM;Geschwind M;Glaser CA;Honnorat J;Höftberger R;Iizuka T;Irani SR;Lancaster E;Leypoldt F;Prüss H;Rae-Grant A;Reindl M;Rosenfeld MR;Rostásy K;Saiz A;Venkatesan A;Vincent A;Wandinger KP;Waters P;Dalmau J
通讯作者：
Dalmau J
影响因子：
48
作者：
Dalmau, Josep;Gleichman, Amy J.;Hughes, Ethen G.;Rossi, Jeffrey E.;Peng, Xiaoyu;Lai, Meizan;Dessain, Scott K.;Rosenfeld, Mynna R.;Balice-Gordon, Rita;Lynch, David R.
通讯作者：
Lynch, David R.