The partner of inscuteable/discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila
The partner of inscuteable/discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila
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DOI：
10.1016/s0092-8674(01)00444-5
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发表时间：
2001-08-10
期刊：
影响因子：
64.5
通讯作者：
Schweisguth, F
中科院分区：
文献类型：
--
作者：
Bellaïche, Y;Radovic, A;Schweisguth, F
卷曲 (Fz) 信号传导调节脊椎动物和无脊椎动物的细胞极性。在果蝇中，Fz 使感觉器官前体细胞 (pl) 沿着诺姆的前后轴定向不对称分裂。平面极化涉及 pi 细胞顶端-基底极性的重塑。 Discs-large (Dlg) 和 Partner of Inscuteable (Pins) 蛋白在前皮质积累，而 Bazooka (Baz) 则重新定位到后皮质。 Dig 直接与 Pins 交互并调节 Pins 和 Baz 的本地化。 Pins 与 Fz 一起作用以向后定位 Baz，但 Baz 不需要向前定位 Pins。最后，Baz 和 Dig/Pins 复合体是 Numb 不对称定位所必需的。因此，Dig/Pins 复合物响应 Fz 信号传导，在 pl 细胞中建立平面不对称性。
Frizzled (Fz) signaling regulates cell polarity in both vertebrates and invertebrates. In Drosophila, Fz orients the asymmetric division of the sensory organ precursor cell (pl) along the antero-posterior axis of the notum. Planar polarization involves a remodeling of the apical-basal polarity of the pi cell. The Discs-large (Dlg) and Partner of Inscuteable (Pins) proteins accumulate at the anterior cortex, while Bazooka (Baz) relocalizes to the posterior cortex. Dig interacts directly with Pins and regulates the localization of Pins and Baz. Pins acts with Fz to localize Baz posteriorly, but Baz is not required to localize Pins anteriorly. Finally, Baz and the Dig/Pins complex are required for the asymmetric localization of Numb. Thus, the Dig/Pins complex responds to Fz signaling to establish planar asymmetry in the pl cell.