A noninvasive comparative study of myocardial strains in ischemic canine hearts using tagged MRI in 3-D.
A noninvasive comparative study of myocardial strains in ischemic canine hearts using tagged MRI in 3-D.
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DOI：
10.1152/ajpheart.1995.268.5.h1918
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发表时间：
1995-05
期刊：
影响因子：
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通讯作者：
H. Azhari;J. Weiss;W. Rogers;C. Siu;E. Shapiro
中科院分区：
文献类型：
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作者：
H. Azhari;J. Weiss;W. Rogers;C. Siu;E. Shapiro
心肌功能的局部降低长期以来一直被用于左心室缺血区域的无创检测和定位。在这项研究中，我们比较了13种不同的心肌应变指数区分缺血和非缺血组织的能力。使用磁共振成像与标记和三维重建，我们非侵入性地跟踪了24个心肌立方在每个9只犬心脏急性缺血引起的冠状动脉结扎的变形。单星蓝染色用于死后缺血评估。使用“t”统计量评价每个指数区分正常和缺血区的能力。最好的区分是通过内膜面积应变[t = 7.5 +/- 3.0（SD）]（内膜表面收缩收缩的局部测量）和内膜主应变的大小（t = 7.0 +/- 1.9）获得的。室壁增厚（t = 6.1 ± 2.3）是第三好的功能指标。通过单星蓝染色评估，相同的三个指标与灌注最密切相关。这些结果表明，这些是较好的功能指标，缺血心肌区域的映射。
Regional reduction in myocardial function has long been utilized for noninvasive detection and localization of ischemic regions in the left ventricle. In this study, we compared the ability of 13 different myocardial strain indexes to discriminate between ischemic and nonischemic tissue. Using magnetic resonance imaging with tagging and three-dimensional reconstruction, we noninvasively tracked the deformation of 24 myocardial cuboids in each of nine canine hearts with acute ischemia induced by coronary artery ligation. Monastral blue staining was used for postmortem assessment of ischemia. The ability of each index to discriminate between normal and ischemic zones was evaluated using the "t" statistic. The best discrimination was obtained by the endocardial area strain [t = 7.5 +/- 3.0 (SD)], a local measure of systolic shrinkage on the endocardial surface, and by the magnitude of the endocardial principal strain (t = 7.0 +/- 1.9). Transmural wall thickening (t = 6.1 +/- 2.3) was the third best functional index. The same three indexes correlated most closely with perfusion, as assessed by monastral blue staining. These findings imply that these are the preferable functional indexes for mapping of ischemic myocardial regions.