Their last will and testament: dying immune cells protect the urinary system with extracellular DNA traps.
Their last will and testament: dying immune cells protect the urinary system with extracellular DNA traps.
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DOI：
10.1016/j.kint.2023.05.021
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发表时间：
2023-08
影响因子：
19.6
通讯作者：
N. Steers;J. Barasch
中科院分区：
文献类型：
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作者：
N. Steers;J. Barasch
与大多数上皮器官一样，膀胱和肾脏可以直接被进化而来的细菌侵入。上皮细胞和免疫细胞试图通过生物物理和化学机制来阻止这种感染。 Goldspinket 等人将肾髓质中的 Na+ 梯度与死亡细胞（即中性粒细胞和巨噬细胞的爆炸性死亡）建立的免疫防御联系起来，从而产生细胞外 DNA 陷阱。描绘了从 Na+ 浓度到免疫死亡的途径。
Like most epithelial organs, the bladder and kidney can be directly accessed by bacteria evolved for invasion. Epithelia and immune cells attempt to stymie this infection with biophysical and chemical mechanisms. Goldspinket al.connected the Na+gradient in the kidney medulla with an immune defense mounted by dead cells (namely, the explosive death of neutrophils and macrophages), resulting in extracellular DNA traps. The pathway from Na+concentration to immune death is depicted.