Rearing environment differentially modulates cocaine self-administration after opioid pretreatment: A behavioral economic analysis
Rearing environment differentially modulates cocaine self-administration after opioid pretreatment: A behavioral economic analysis
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DOI：
10.1016/j.drugalcdep.2016.07.026
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发表时间：
2016-10-01
影响因子：
4.2
通讯作者：
Bardo, Michael T.
中科院分区：
文献类型：
--
作者：
Hofford, Rebecca S.;Beckmann, Joshua S.;Bardo, Michael T.
背景资料：研究表明，以前在发育过程中的经历，特别是压力，可以改变生物体在以后生活中对阿片类药物的反应。鉴于以往的文献阿片类药物调制可卡因自我管理，目前的研究提出了大鼠在丰富的条件（EC）或隔离条件（IC），并采用行为经济学研究的影响，纳洛酮和吗啡对可卡因self-administration.Methods：EC和IC大鼠进行训练，以杠杆按可卡因使用一个会话内的需求程序。该程序通过减少在整个会话期间获得的可卡因剂量来测量可卡因价格变化下的可卡因消费。大鼠能够在FRI上自我给予可卡因;每10分钟可卡因剂量系统性降低（0.75-0.003 mg/kg/输注可卡因）。在此程序达到稳定后，大鼠随机预处理0，0.3，1，或3毫克/公斤纳洛酮每3天一次，然后随机预处理0，0.3，1，或3毫克/公斤吗啡每3天一次。结果：纳洛酮仅降低了IC大鼠可卡因的必需值，而对IC大鼠的可卡因消耗量无显著影响。然而，吗啡降低了可卡因的必要价值和可卡因的消费在零价格在EC和IC大鼠。结论：这些结果表明，在确定阿片类药物的疗效时，应考虑发展过程中的环境经验，特别是对物质滥用的治疗。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Background: Research has shown that previous experiences during development, especially if stressful, can alter an organism's response to opioids later in life. Given the previous literature on opioid modulation of cocaine self-administration, the current study raised rats in either an enriched condition (EC) or isolated condition (IC) and employed behavioral economics to study the effects of naltrexone and morphine on cocaine self-administration.Methods: EC and IC rats were trained to lever press for cocaine using a within-session demand procedure. This procedure measured cocaine consumption under changing cocaine price by decreasing the dose of cocaine earned throughout a session. Rats were able to self-administer cocaine on a FRI; every 10 min the cocaine dose was systematically decreased (0.75-0.003 mg/kg/infusion cocaine). After reaching stability on this procedure, rats were randomly pretreated with 0, 0.3, 1, or 3 mg/kg naltrexone once every 3 days, followed by random pretreatments of 0, 0.3,1, or 3 mg/kg morphine once every 3 days. Economic demand functions were fit to each rat's cocaine consumption from each pretreatment, and appropriate mathematical parameters were extracted and analyzed.Results: Naltrexone decreased the essential value of cocaine in IC rats only. However, morphine decreased the essential value of cocaine and the consumption of cocaine at zero price in both EC and IC rats.Conclusion: These results indicate that environmental experiences during development should be considered when determining the efficacy of opioid drugs, especially for the treatment of substance abuse. (C) 2016 Elsevier Ireland Ltd. All rights reserved.