The anti-inflammatory effects of Pyrolae herba extract through the inhibition Of the expression of inducible nitric oxide synthase (iNOS) and NO production
The anti-inflammatory effects of Pyrolae herba extract through the inhibition Of the expression of inducible nitric oxide synthase (iNOS) and NO production
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DOI：
10.1016/j.jep.2007.01.036
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发表时间：
2007-05-30
影响因子：
5.4
通讯作者：
Choi, Wahn Soo
中科院分区：
文献类型：
--
作者：
Lee, Mu Hong;Lee, Jeong Min;Choi, Wahn Soo
在韩国和中国，鹿蹄草（PH）提取物已被用作抗炎民间药物，研究了其抗炎作用，使用花生四烯酸，12-O-十四酰基佛波醇13-乙酸酯或角叉菜胶诱导的水肿测定。还使用醋酸诱导的扭体模型在小鼠中测试PH的抗伤害感受活性。PH值呈剂量依赖性，有显著性差异（P
The extract of Pyrolae herba (PH), which has been used as an anti-inflammatory folk remedy in Korea and China, was investigated for its antiinflammatory action using arachidonic acid, 12-O-tetradecanoylphorbol 13-acetate or carrageenan-induced edema assays. The anti-nociceptive activity of PH was also tested in mice using the acetic acid-induced writhing model. PH showed dose-dependent and significant (P