Olfactory associative conditioning in infant rats with brain stimulation as reward: II. Norepinephrine mediates a specific component of the bulb response to reward.
Olfactory associative conditioning in infant rats with brain stimulation as reward: II. Norepinephrine mediates a specific component of the bulb response to reward.
复制标题
以脑刺激作为奖励的幼年大鼠的嗅觉联想调节：II。
DOI：
10.1037//0735-7044.105.6.843
复制
发表时间：
1991
影响因子：
1.9
通讯作者：
Sullivan,RM
中科院分区：
文献类型：
--
作者：
Wilson,DA;Sullivan,RM
One of the circuits modified by early olfactory learning is in the olfactory bulb. Specifically, response patterns of mitral-tufted cells are modified by associative conditioning during the early postnatal period. In addition, previous work has demonstrated that mitral-tufted cell single units respond to both olfactory conditioned stimuli and rewarding stimulation of the medial forebrain bundle-lateral hypothalamus (MFB-LH). The present study suggests that norepinephrine β-receptor activation is required for early olfactory learning using MFB-LH stimulation as reward. Propranolol injected before odor–MFB-LH pairings blocks the acquisition of conditioned behavioral responses and their neural correlates to the conditioned odor. Furthermore, propranolol blocks a specific class of the mitral-tufted cell responses to MFB-LH reward stimulation. The relationship of this response to reward and early learning is discussed.(PsycINFO Database Record (c) 2016 APA, all rights reserved)
