IGFBP-1 in cancer: expression, molecular mechanisms, and potential clinical implications.
IGFBP-1 in cancer: expression, molecular mechanisms, and potential clinical implications.
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发表时间：
2021
影响因子：
2.2
通讯作者：
Yi-Wei Lin;Xuefen Weng;Bin Huang;Hai-Peng Guo;Yiwei Xu;Yu-Hui Peng
中科院分区：
文献类型：
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作者：
Yi-Wei Lin;Xuefen Weng;Bin Huang;Hai-Peng Guo;Yiwei Xu;Yu-Hui Peng
胰岛素样生长因子结合蛋白-1(IGFBP-1)属于胰岛素样生长因子(IGF)系统，在正常生长发育和多种肿瘤的病理生理过程中起着不可或缺的作用。IGFBP-1已被证明与多种肿瘤的风险相关，并通过不同的分子机制在调节肿瘤的增殖、迁移、侵袭和黏附等行为中发挥重要作用。研究发现，IGFBP-1在肿瘤中的生物学作用与其磷酸化状态以及IGF依赖和非依赖机制有关。本文综述了IGFBP-1在正常生理学中的作用，IGFBP-1在一系列常见肿瘤中的异常表达及其分子机制，并讨论了IGFBP-1作为癌症诊断或预后生物标记物的潜在临床意义。
Insulin-like growth factor binding protein-1 (IGFBP-1) belongs to the insulin-like growth factor (IGF) system, which plays an indispensable role in normal growth and development, and in the pathophysiology of various tumors. IGFBP-1 has been shown to be associated with the risk of various tumors, and has a vital function in regulating tumor behaviors such as proliferation, migration, invasion and adhesion through different molecular mechanisms. The biological actions of IGFBP-1 in cancer are found to be related to its phosphorylation state, and the IGF-dependent and -independent mechanisms. In this review, we provided an overview of IGFBP-1 in normal physiology, and its aberrantly expression and the underlying molecular mechanisms in a range of common tumors, as well as discussed the potential clinical implications of IGFBP-1 as diagnostic or prognostic biomarkers in cancer.