Drosophila type XV/XVIII collagen, Mp, is involved in Wingless distribution
Drosophila type XV/XVIII collagen, Mp, is involved in Wingless distribution
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DOI：
10.1016/j.matbio.2011.03.008
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发表时间：
2011-05-01
期刊：
影响因子：
6.9
通讯作者：
Ohtsuka, Aiji
中科院分区：
文献类型：
--
作者：
Momota, Ryusuke;Naito, Ichiro;Ohtsuka, Aiji
多重蛋白（Mp）是脊椎动物胶原XV和XVIII的果蝇直向同源物。与它们一样，Mp广泛分布于发育胚胎的基底膜中，包括中枢和外周神经系统中的神经母细胞、肠道的内脏肌和收缩性成心肌细胞的基底膜。在这里，我们报告的突变幼虫轴承piguBac转座子插入表现出减少MP生产与腹部表皮和翅缘缺陷，感觉器官畸形和对物理刺激的敏感性受损。其他发现包括与异常IV型胶原沉积相关的脂肪体的异常超微结构，以及无翼沉积减少。总的来说，这些发现是一致的概念，即MP是所需的适当的形成和/或维持基底膜，MP可能参与建立无翅信号梯度在果蝇胚胎。(C)2011 Elsevier B. V.保留所有权利。
Multiplexin (Mp) is the Drosophila orthologue of vertebrate collagens XV and XVIII. Like them, Mp is widely distributed in the basement membranes of the developing embryos, including those of neuroblasts in the central and peripheral nervous systems, visceral muscles of the gut, and contractile cardioblasts. Here we report the identification of mutant larvae bearing piguBac transposon insertions that exhibit decrease Mp production associated with abdominal cuticular and wing margin defects, malformation of sensory organs and impaired sensitivity to physical stimuli. Additional findings include the abnormal ultrastructure of fatbody associated with abnormal collagen IV deposition, and reduced Wingless deposition. Collectively, these findings are consistent with the notion that Mp is required for the proper formation and/or maintenance of basement membrane, and that Mp may be involved in establishing the Wingless signaling gradients in the Drosophila embryo. (C) 2011 Elsevier B.V. All rights reserved.