Distribution and Characteristics of Meibomian Gland Dysfunction Subtypes: A Multicenter Study in South Korea.
Distribution and Characteristics of Meibomian Gland Dysfunction Subtypes: A Multicenter Study in South Korea.
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DOI：
10.3341/kjo.2018.0104
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发表时间：
2019-06-01
影响因子：
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通讯作者：
Kim, Hyun Seung
中科院分区：
文献类型：
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作者：
Eom, Youngsub;Na, Kyung Sun;Kim, Hyun Seung
目的：探讨韩国汗腺功能障碍(MGD)的分布、特点及对症状性MGD患者的治疗模式。对每个患者的上、下眼睑的中央八个腺体进行了表现性检测。每只上、下睑分别分为3种亚型：不明显梗阻型(低产无盖缘异常)、明显梗阻(低产伴盖缘异常)和高分泌型(高位产伴盖缘异常)。结果：上睑中央8个腺体的平均可表达腺体数(3.9±2.6)个，明显高于下睑(2.2±2.4)个，P<0.001.0 5。最常见的亚型是明显梗阻型MGD，其次是上、下睑分泌型和不明显梗阻型。在196名受试者中，38人(19.4%)上眼皮和下眼皮被归为不同的类别。眼皮卫生是最常用的治疗方法(74.5%)，其次是使用润滑剂眼药水(71.5%)。医生倾向于根据上眼睑的亚型而不是下眼睑的亚型来确定治疗方案。结论：大多数受试者被归类为MGD的明显梗阻型，19.4%的受试者上、下眼睑属于不同的亚型。眼皮卫生是MGD患者最常用的治疗方法，治疗模式大多基于上眼睑的亚型来确定。
PURPOSE: We sought to evaluate the distribution and characteristics of meibomian gland dysfunction (MGD) and the treatment patterns for symptomatic MGD patients in South Korea.METHODS: One hundred ninety-six right eyes of 196 MGD patients were enrolled. For each patient, meibum expressibility in the central eight glands in both the upper and lower eyelids was examined. Each upper and lower eyelid was separately classified into one of the following three subtypes: nonobvious obstructive (low-delivery without lid margin abnormality), obvious obstructive (low-delivery with lid margin abnormality), and hypersecretory (high-delivery with lid margin abnormality). All treatment plans were also recorded.RESULTS: The mean number of expressible glands of the central eight glands in the upper eyelids (3.9 ± 2.6) was significantly higher than that in the lower eyelids (2.2 ± 2.4, p < 0.001). Obvious obstructive MGD was the most common subtype, followed by the hypersecretory and nonobvious obstructive subtypes in both the upper and lower eyelids. Of the 196 subjects, 38 (19.4%) had upper and lower eyelids that were assigned to different categories. Eyelid hygiene was the most prescribed treatment (74.5%), followed by lubricant eye drop usage (71.5%). Physicians tended to determine treatment plans based on the subtype of the upper eyelid rather than that of the lower eyelid.CONCLUSIONS: The majority of subjects were classified as having the obvious obstructive subtype of MGD, and 19.4% had upper and lower eyelids that were different subtypes. Eyelid hygiene was the most prescribed treatment for MGD patients, and treatment patterns were mostly determined based on the subtype of the upper eyelids.