Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever.
Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever.
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DOI：
10.1038/nm.4396
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发表时间：
2017-10
期刊：
影响因子：
82.9
通讯作者：
Geisbert TW
中科院分区：
文献类型：
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作者：
Mire CE;Cross RW;Geisbert JB;Borisevich V;Agans KN;Deer DJ;Heinrich ML;Rowland MM;Goba A;Momoh M;Boisen ML;Grant DS;Fullah M;Khan SH;Fenton KA;Robinson JE;Branco LM;Garry RF;Geisbert TW
There are no approved treatments for Lassa fever, which is endemic to the same regions of West Africa that were recently devastated by Ebola. Here we show that a combination of human monoclonal antibodies that cross-react with the glycoproteins of all four clades of Lassa virus is able to rescue 100% of cynomolgus macaques when treatment is initiated at advanced stages of disease, including up to 8 d after challenge.
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影响因子：
3.1
作者：
JAHRLING, PB;PETERS, CJ
通讯作者：
PETERS, CJ
影响因子：
64.8
作者：
Thi, Emily P.;Mire, Chad E.;Lee, Amy C. H.;Geisbert, Joan B.;Zhou, Joy Z.;Agans, Krystle N.;Snead, Nicholas M.;Deer, Daniel J.;Barnard, Trisha R.;Fenton, Karla A.;MacLachlan, Ian;Geisbert, Thomas W.
通讯作者：
Geisbert, Thomas W.
影响因子：
158.5
作者：
MCCORMICK, JB;KING, IJ;BELMONTWILLIAMS, R
通讯作者：
BELMONTWILLIAMS, R
影响因子：
11.8
作者：
Amorosa, Valerianna;MacNeil, Adam;Nichol, Stuart T.
通讯作者：
Nichol, Stuart T.
影响因子：
--
作者：
EMOND, RTD;BANNISTER, B;BOWEN, ETW
通讯作者：
BOWEN, ETW