Dietary restriction and beta-cell sensitivity to glucose in adult male rhesus monkeys.
Dietary restriction and beta-cell sensitivity to glucose in adult male rhesus monkeys.
复制标题
成年雄性恒河猴的饮食限制和β细胞对葡萄糖的敏感性。
DOI：
10.1093/gerona/58.7.b598
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Kemnitz,JosephW
中科院分区：
文献类型：
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作者：
Gresl,TheresaA;Colman,RickiJ;Havighurst,ThomasC;Allison,DavidB;Schoeller,DaleA;Kemnitz,JosephW
我们研究了饮食限制 (DR) 和年龄对恒河猴 β 细胞功能和外周胰岛素敏感性的影响。向对照动物（C）每天提供约 8 小时的半纯化饮食，或向限制动物（R）提供约 70% 的基线摄入量，持续 10 年。使用静脉内葡萄糖耐量试验期间的血浆葡萄糖、C 肽和胰岛素浓度来鉴定 C 肽分泌和动力学的最小模型以及标记的葡萄糖动力学的 2 室最小模型。 R 猴的体脂较少，基础 β 细胞对葡萄糖 (Øb) 的敏感性较低，胰岛素敏感性较高，第一相血浆胰岛素反应较低。 DR 没有显着影响第一相和第二相 β 细胞对葡萄糖的敏感性。身体脂肪指数高度预测 DR 对 Øb、空腹胰岛素浓度和胰岛素对葡萄糖的反应的影响。 R 猴中外周胰岛素敏感性的增强与较低的 Øb 密切相关。
We examined the effects of dietary restriction (DR) and age on ß-cell function and peripheral insulin sensitivity in rhesus monkeys. A semipurified diet was provided either ad libitum for ∼8 hours/day to controls (C) or as ∼70% of baseline intake to restricted (R) animals for 10 years. The minimal model of C-peptide secretion and kinetics and the labeled 2-compartment minimal model of glucose kinetics were identified using plasma glucose, C-peptide, and insulin concentrations during an intravenous glucose tolerance test. R monkeys had less body fat, lower basal ß-cell sensitivity to glucose (Øb), greater insulin sensitivity, and lower first-phase plasma insulin response. DR did not significantly affect first-phase and second-phase ß-cell sensitivity to glucose. Indices of body fatness were highly predictive of the effect of DR on Øb, fasting insulin concentration and insulin responses to glucose. Enhanced peripheral insulin sensitivity among R monkeys was strongly correlated with lower Øb.