Copper(I)-Secondary Diamine Complex-Catalyzed Enantioselective Conjugate Boration of Linear β,β-Disubstituted Enones
Copper(I)-Secondary Diamine Complex-Catalyzed Enantioselective Conjugate Boration of Linear β,β-Disubstituted Enones
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DOI：
10.1021/ol101691p
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发表时间：
2010-09-17
期刊：
影响因子：
5.2
通讯作者：
Shibasaki, Masakatsu
中科院分区：
文献类型：
--
作者：
Chen, I-Hon;Kanai, Motomu;Shibasaki, Masakatsu
一种铜（I）手性仲二胺（L-e）配合物催化β，β-二取代烯酮的对映选择性共轭硼化反应，产率高达99%ee。产物手性叔有机硼酸酯可以转化为酮之间的对映体富集的交叉羟醛产物，而不发生任何外消旋反应。
A copper(I) chiral secondary diamine (L-e) complex catalyzes an enantioselective conjugate boration of beta,beta-disubstituted enones in high yields and up to 99% ee. Product chiral tertiary organoboronates can be converted to enantiomerically enriched cross-aldol products between ketones without any racemization.