Air pollution and allergy: Experimental studies on modulation of allergen release from pollen by air pollutants
Air pollution and allergy: Experimental studies on modulation of allergen release from pollen by air pollutants
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DOI：
10.1159/000237511
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发表时间：
1997-01-01
影响因子：
2.8
通讯作者：
Ring, J
中科院分区：
文献类型：
--
作者：
Behrendt, H;Becker, WM;Ring, J
事实上，过敏性疾病的患病率增加是一个普遍接受的世界性现象。这种增长的原因尚不清楚：只存在假设的概念。对东欧和西欧人口进行比较的流行病学研究表明，在呼吸道特应性疾病的流行率方面存在显著差异，东欧的发病率较低。与此同时，还描述了不同的空气污染模式，即“经典”I型，其特征是东部普遍存在的SO2和灰尘，以及“现代”II型，其特征是有机化合物、细颗粒物和臭氧，在西部更为突出。在多变量回归分析中，II型与IgE介导的变态反应的患病率增加相关。从德国西部多环芳烃含量高的工业区收集的花粉粒，但在德国东部没有，显示出与空气中的颗粒团聚。花粉在体外暴露于颗粒表明形态变化和增加过敏原释放的花粉。花粉在体外暴露于不同湿度条件下的气态污染物（SO2和NO2）导致SO2诱导的，但不是NO2诱导的花粉过敏原释放的减少。它的结论是草花粉过敏原的生物利用度可能会调制空气污染物，支持花粉和污染物之间的相互作用的概念，在大气中的生物体外，这反过来可能会影响过敏相关的现象。
The fact that allergic diseases increase in prevalence is a generally accepted and worldwide phenomenon. The causes for this increase are not known: only hypothetical concepts exist. Epidemiological studies comparing Eastern and Western European populations have shown a striking difference in the prevalence of respiratory atopic diseases, which is lower in the East. At the same time, different patterns of air pollution have been described, namely 'classical' type I, characterized by SO2 and dust prevailing in the East, and 'modern' type II, characterized by organic compounds, fine particles and ozone, which is more prominent in the West. Type II was associated in multivariate regression analysis with increased prevalence of IgE-mediated allergy. Pollen grains collected from industrial regions with high polyaromatic hydrocarbon load in West Germany, but not in East Germany, were shown to be agglomerated with airborne particles. In vitro exposure of pollen to particles indicated morphological changes and increased allergen release from the pollen. In vitro exposure of pollen to gaseous pollutants (SO2 and NO2) under different conditions of humidity resulted in SO2-induced, but not NO2-induced reduction of allergen release from pollen. It is concluded that the bioavailability of grass pollen allergens may be modulated by air pollutants, supporting the concept of an interaction between pollen and pollutants in the atmosphere outside the organism which in turn may affect allergy-relevant phenomena.