Vitamin D: two dihydroxylated metabolites are required for normal chicken egg hatchability.
Vitamin D: two dihydroxylated metabolites are required for normal chicken egg hatchability.
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维生素 D：正常的鸡蛋孵化率需要两种二羟基代谢物。
DOI：
10.1126/science.684411
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发表时间：
1978
期刊：
影响因子：
56.9
通讯作者：
A. Norman
中科院分区：
文献类型：
--
作者：
H. Henry;A. Norman
当母鸡从孵化到性成熟时，以1，25-二羟基维生素D3 [1，25（OH）2D 3]作为其胆钙化醇（维生素D3）的唯一来源，可育蛋似乎发育正常，但不能孵化。当母鸡接受1，25（OH）2D 3和24 R，25-二羟维生素D3 [24，25（OH）2D 3]的组合时，获得与给予维生素D3的母鸡相当的孵化率。这些结果表明，24，25（OH）2D 3的生物学作用以前没有认识到。
When hens are raised to sexual maturity from hatching with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] as their sole source of cholecalciferol (vitamin D3), fertile eggs appear to develop normally but fail to hatch. When hens receive a combination of 1,25(OH)2D3 and 24R,25-dihydroxyvitamin D3 [24,25(OH)2D3], hatchability equivalent to that with hens given vitamin D3 is obtained. These results suggest a biological role for 24,25(OH)2D3 not previously recognized.