Diminished language lateralization in schizophrenia corresponds to impaired inter-hemispheric functional connectivity
Diminished language lateralization in schizophrenia corresponds to impaired inter-hemispheric functional connectivity
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DOI：
10.1016/j.schres.2011.10.011
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发表时间：
2012-02-01
影响因子：
4.5
通讯作者：
Hendler, Talma
中科院分区：
文献类型：
--
作者：
Bleich-Cohen, Maya;Sharon, Haggai;Hendler, Talma
简介：在精神分裂症患者中，一个一致的脑成像发现是语言不对称性降低，这在首次发作患者中已经很明显，因此为该疾病的生物标志物进行了辩论。然而，它对精神分裂症的特异性是值得怀疑的。此外，虽然先前的研究表明，增强的右半球激活是这种减少不对称的基础，但这种异常的机制尚不清楚。本研究的目的是通过功能连接分析，探讨大脑半球间的关系在这种异常中的作用，左额下回（IFG）激活驱动。为了测试障碍的特异性，我们比较了精神分裂症患者不仅健康对照，但也与强迫症（OCD）患者。方法：功能磁共振成像（fMRI）应用在3组听觉动词生成任务。位于IFG的BA 44/45中的与语言相关的激活被用于区域估计大脑的不对称性和用于评估半球间的功能connections.Results：精神分裂症，但不是强迫症患者表现出减少语言不对称性的IFG相对于健康对照组和减少左右IFG之间的功能连接。重要的是，减少interhemispheric功能连接的IFG与更多的阴性症状之间的精神分裂症patients.Conclusions：减少语言相关的不对称的IFG似乎是精神分裂症的早期障碍特异性神经标记，支持其致病作用。这种区域异常与大脑半球间功能连接减少和症状严重程度的关系支持了大规模脑结构紊乱在精神分裂症中的作用。这可能与已知的胼胝体结构异常导致功能性半球连接障碍有关。(C)2011 Elsevier B. V.保留所有权利。
Introduction: A consistent brain imaging finding in schizophrenia is decreased language-asymmetry, already evident in first episode patients, thus arguing for a biomarker of the disorder. Nonetheless, its specificity to schizophrenia is questionable. Furthermore, while previous studies suggested that enhanced right hemisphere activation underlies this diminished asymmetry, the mechanism for this anomaly is yet unknown. This study aimed to examine the role of inter-hemispheric relations in such abnormality through functional connectivity analysis driven by left inferior frontal gyrus (IFG) activation. To test for disorder specificity we compared schizophrenia patients not only to healthy controls but also to patients with obsessive compulsive disorder (OCD).Methods: Functional magnetic resonance imaging (fMRI) was applied during an auditory verb generation task in the 3 groups. Language-related activation in BA44/45 located in the IFG was used for regional estimation of brain asymmetry and for assessment of inter-hemispheric functional connectivity.Results: Schizophrenia, but not OCD patients showed reduced language asymmetry in the IFG relative to healthy controls and diminished functional connectivity between the left and right IFG. Importantly, decreased interhemispheric functional connectivity in the IFG was related to more negative symptoms among the schizophrenia patients.Conclusions: Diminished language-related asymmetry in the IFG seems to be an early disorder specific neural marker of schizophrenia, supporting its pathogenic role. The relation of this regional abnormality to reduced inter-hemispheric functional connectivity and symptom severity supports the role of large-scale brain disorganization in schizophrenia. This may relate to the known structural abnormalities of the corpus callosum leading to functional hemispheric dysconnection. (C) 2011 Elsevier B.V. All rights reserved.