Fluorescent hydroxyapatite‐loaded biodegradable polymer nanoparticles with folate decoration for targeted imaging
Fluorescent hydroxyapatite‐loaded biodegradable polymer nanoparticles with folate decoration for targeted imaging
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DOI：
10.1002/aic.14210
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发表时间：
2013-12
期刊：
影响因子：
3.7
通讯作者：
Jie Pan;D. Wan;Yuxia Bian;Hongfan Sun;C. Zhang;F. Jin;Zhiqi Huang;Jinlong Gong
中科院分区：
文献类型：
--
作者：
Jie Pan;D. Wan;Yuxia Bian;Hongfan Sun;C. Zhang;F. Jin;Zhiqi Huang;Jinlong Gong
制备了用于癌细胞靶向成像的发光羟基磷灰石（HAP）负载的生物相容性纳米颗粒（NPs）。目前，使用荧光探针的细胞成像是用于癌症早期诊断的重要技术。与量子点相比，发光羟基磷灰石是一种新型的荧光材料，具有毒性低、生物相容性好、热稳定性好、耐腐蚀、价格低廉等优点。因此，发光HAP具有作为生物荧光探针的巨大潜力。但发光HAP不溶于水，灵敏度低，限制了其在细胞成像领域的应用。利用靶向分子对纳米粒进行表面修饰，实现纳米粒的靶向功能。因此，制备了具有低毒性、高灵敏度和良好光稳定性的新型荧光纳米颗粒，用于癌细胞的靶向成像。本研究初步探索了发光HAP在靶向细胞成像领域的应用。这种纳米粒子平台将成为分子成像和医学诊断的一种有前途的工具，特别是在早期阶段检测癌症。© 2013美国化学工程师学会AIChE J，59：4494-4501，2013
The preparation of the luminescent hydroxyapatite (HAP)-loaded biocompatible nanoparticles (NPs) for targeted imaging of cancer cells is described. Currently, cellular imaging using fluorescent probes is an important technique for the early diagnosis of cancer. Compared with the quantum dots, luminescent HAP is a new fluorescent material with many advantages such as low toxicity, biocompatibility, thermal stability, resistance to erosion, and low prices. Thus, luminescent HAP has enormous potential to be used as biological fluorescent probes. However, luminescent HAP is water-insoluble, low sensitivity, which limit its application in the field of cellular imaging. Surface modification of NPs with targeting molecule was carried out to achieve its target function. Thus, novel fluorescent NPs with low toxicity, high sensitivity, and good photostability were prepared to be used for targeted imaging of cancer cells. This study initially explored the applications of luminescent HAP in the field of targeted cellular imaging. This NPs platform will be a promising tool for molecular imaging and medical diagnostics, especially the detection of cancer at its early stage. © 2013 American Institute of Chemical Engineers AIChE J, 59: 4494–4501, 2013