The evolution of mammalian gene families.
The evolution of mammalian gene families.
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DOI：
10.1371/journal.pone.0000085
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发表时间：
2006-12-20
期刊：
影响因子：
3.7
通讯作者：
Hahn MW
中科院分区：
文献类型：
--
作者：
Demuth JP;De Bie T;Stajich JE;Cristianini N;Hahn MW
基因家族是一组可能具有高度相似功能的同源基因。由于特定血统的基因复制和基因丢失导致的家庭规模差异可能为塑造哺乳动物基因组的进化力量提供线索。在这里，我们分析了人类、黑猩猩、小鼠、大鼠和狗的整个基因组中包含的基因家族。总体而言，我们发现，在哺乳动物共同祖先中存在的9990个家庭中，超过一半的家庭沿着至少一个谱系扩大或收缩。此外，我们发现大量的家族从一个或多个哺乳动物基因组中完全消失，并且在哺乳动物共同祖先之后出现了类似数量的基因家族。沿着通向现代人的谱系，我们推断自黑猩猩分裂以来，获得了689个基因，丢失了86个基因，其中包括可能由适应性自然选择驱动的变化。我们的结果表明，人类和黑猩猩在他们的基因序列上至少有6%的差异(22,000个基因中的1,418个)，这与经常提到的同源核苷酸序列之间1.5%的差异形成了鲜明对比。这种基因得失的基因组“旋转门”代表了人类与近亲之间的大量基因差异。
Gene families are groups of homologous genes that are likely to have highly similar functions. Differences in family size due to lineage-specific gene duplication and gene loss may provide clues to the evolutionary forces that have shaped mammalian genomes. Here we analyze the gene families contained within the whole genomes of human, chimpanzee, mouse, rat, and dog. In total we find that more than half of the 9,990 families present in the mammalian common ancestor have either expanded or contracted along at least one lineage. Additionally, we find that a large number of families are completely lost from one or more mammalian genomes, and a similar number of gene families have arisen subsequent to the mammalian common ancestor. Along the lineage leading to modern humans we infer the gain of 689 genes and the loss of 86 genes since the split from chimpanzees, including changes likely driven by adaptive natural selection. Our results imply that humans and chimpanzees differ by at least 6% (1,418 of 22,000 genes) in their complement of genes, which stands in stark contrast to the oft-cited 1.5% difference between orthologous nucleotide sequences. This genomic “revolving door” of gene gain and loss represents a large number of genetic differences separating humans from our closest relatives.
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DOI：
10.1073/pnas.0400975101
发表时间：
2004-06-29
影响因子：
11.1
作者：
Boussau, B;Karlberg, EO;Andersson, SGE
通讯作者：
Andersson, SGE
影响因子：
7
作者：
Gilad, Y;Man, O;Glusman, G
通讯作者：
Glusman, G
两个层面的进化：基因和形态。
影响因子：
9.8
作者：
Carroll, SB
通讯作者：
Carroll, SB
影响因子：
64.8
作者：
Bustamante, CD;Fledel-Alon, A;Clark, AG
通讯作者：
Clark, AG
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y