DEVELOPMENTAL AND MATURATIONAL CHANGES IN HUMAN BLOOD LYMPHOCYTE SUBPOPULATIONS
DEVELOPMENTAL AND MATURATIONAL CHANGES IN HUMAN BLOOD LYMPHOCYTE SUBPOPULATIONS
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DOI：
10.1016/0167-5699(92)90157-3
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发表时间：
1992-06-01
期刊：
影响因子：
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通讯作者：
DEBRUYERE, M
中科院分区：
文献类型：
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作者：
HANNET, I;ERKELLERYUKSEL, F;DEBRUYERE, M
最近应用流式细胞术免疫分型的儿童疾病状态突出了需要可靠的淋巴细胞数据范围在正常的婴儿和儿童。在儿科人类免疫缺陷病毒（HIV）疾病的管理和DiGeorge综合征的诊断中，T细胞计数起着至关重要的作用，从成人正常范围数据外推具有误导性。在这里，110名正常儿科受试者分为新生儿，婴儿（年龄2天至11个月）和儿童（1至6岁和7至17岁）队列的多中心研究的结果。选择这些年龄段是为了反映免疫系统中的成熟事件，如抗原挑战和疫苗接种。儿童的结果进行了比较，在同一中心使用相同的方法评估的101名正常成人。
Recent application of flow cytometric immunophenotyping to childhood disease states has highlighted the need for reliable lymphocyte data ranges in normal infants and children. In the management of pediatric human immunodeficiency virus (HIV) disease and in the diagnosis of DiGeorge syndrome, T-cell enumeration plays a vital role and extrapolation from adult normal range data has been misleading. Here, the findings of a multicenter study of 110 normal pediatric subjects divided into cohorts of newborns, infants (ages 2 days to 11 months) and children (1 to 6 years and 7 to 17 years) are presented. These age divisions were chosen to reflect maturational events in the immune system, such as antigenic challenges and vaccination. Pediatric results were compared to those of 101 normal adults evaluated at the same centers using the same methods.