The causes of cancer in France
The causes of cancer in France
复制标题
DOI：
10.1093/annonc/mdn597
复制
发表时间：
2009-03-01
影响因子：
50.5
通讯作者：
Autier, P.
中科院分区：
文献类型：
--
作者：
Boffetta, P.;Tubiana, M.;Autier, P.
背景资料：虽然外部因素是许多人类癌症的原因，但已知致癌物对特定人群癌症负担的贡献的精确估计一直是稀缺的。方法：我们根据1985年左右暴露频率的数据，估计了2000年法国发生的癌症死亡中已知危险因素的比例。2000年，吸烟导致23.9%的癌症死亡（男性33.4%，女性9.6%），饮酒导致6.9%的癌症死亡（男性9.4%，女性3.0%），慢性感染导致3.7%的癌症死亡。职业是男性癌症死亡的3.7%;缺乏体育活动、超重/肥胖和使用外源性激素是女性癌症死亡的2%-3%。其他风险因素，包括污染物，是负责< 1%的癌症死亡。因此，已知的风险因素解释35.0%的癌症死亡，和15.0%之间从不smokers.Conclusions：虽然癌症死亡率在法国下降，已知的癌症风险因素解释只有少数癌症，吸烟的主要作用。
Background: While external factors are responsible for many human cancers, precise estimates of the contribution of known carcinogens to the cancer burden in a given population have been scarce.Methods: We estimated the proportion of cancer deaths which occurred in France in 2000 attributable to known risk factors, based on data on frequency of exposure around 1985.Results: In 2000, tobacco smoking was responsible for 23.9% of cancer deaths (33.4% in men and 9.6% in women), alcohol drinking for 6.9% (9.4% in men and 3.0% in women) and chronic infections for 3.7%. Occupation is responsible for 3.7% of cancer deaths in men; lack of physical activity, overweight/obesity and use of exogenous hormones are responsible for 2%-3% of cancer deaths in women. Other risk factors, including pollutants, are responsible for < 1% of cancer deaths. Thus, known risk factors explain 35.0% of cancer deaths, and 15.0% among never smokers.Conclusions: While cancer mortality is decreasing in France, known risk factors of cancer explain only a minority of cancers, with a predominant role of tobacco smoking.