Adenosine mediated desensitization of cAMP signaling enhances T-cell responses.
Adenosine mediated desensitization of cAMP signaling enhances T-cell responses.
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DOI：
10.1002/eji.200939586
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发表时间：
2010-02
影响因子：
5.4
通讯作者：
Shi, Yan
中科院分区：
文献类型：
--
作者：
Yang, Ailian;Mucsi, Ashley D.;Desrosiers, Melanie D.;Chen, Jiang-Fan;Schnermann, Juergen B.;Blackburn, Michael R.;Shi, Yan
腺苷长期以来被认为是一种重要的抗炎剂，保护宿主免受过度损伤。据报道，它在抑制免疫活化，特别是T细胞的免疫活化中起重要作用。然而，一般的观察结果是，尽管由于损伤或应激而在受影响的宿主中经常存在高腺苷水平，但T细胞活化的诱导是有效的事件。我们在这里报告，抗原刺激之前，通过TCR/CD 3，暴露的T细胞的腺苷脱敏腺苷受体，从而创建一个时间窗口，T细胞是不敏感的这种无处不在的抑制。来自预先暴露于这种操作的小鼠的T细胞对抗原刺激表现出更强的反应;因此，P1腺苷受体脱敏表现出类似于免疫抑制剂的作用。我们的研究结果表明，腺苷受体脱敏可能是一种机制，T细胞逃避一般抑制在T细胞活化的早期点，并可能成为一个潜在的替代疫苗佐剂。
Adenosine has long been regarded as a crucial anti-inflammatory agent that protects the host from excessive damage. It has been reported to play an important role in suppressing immune activation, particularly that of T cells. However, it is a general observation that induction of T-cell activation is an efficient event despite the high adenosine levels that are often present in the affected host due to injury or stress. We report here that prior to antigenic stimulation via TCR/CD3, exposure of T cells to adenosine desensitizes adeno-sine receptors, so as to create a window of time where the T cells are insensitive to this ubiquitous suppressor. T cells from mice that were pre-exposed to this manipulation showed stronger responses to antigenic stimulation; therefore, the P1 adenosine receptor desensitization demonstrated an adjuvant-like effect. Our results suggest that adenosine receptor desensitization may be a mechanism for T cells to escape the general suppression during early points of T-cell activation and may emerge as a potential alternative for vaccine adjuvants.
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影响因子：
20.3
作者：
Borsellino, Giovanna;Kleinewietfeld, Markus;Falk, Kirsten
通讯作者：
Falk, Kirsten
影响因子：
2.8
作者：
FOX, AC;REED, GE;SILK, BB
通讯作者：
SILK, BB
影响因子：
3.7
作者：
Nakav S;Chaimovitz C;Sufaro Y;Lewis EC;Shaked G;Czeiger D;Zlotnik M;Douvdevani A
通讯作者：
Douvdevani A
影响因子：
5.8
作者：
Fredholm, BB;Irenius, E;Schulte, G
通讯作者：
Schulte, G
影响因子：
4.8
作者：
LINDEN, J
通讯作者：
LINDEN, J