Cognitive-motor dysfunction in Parkinson's disease
Cognitive-motor dysfunction in Parkinson's disease
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DOI：
10.1159/000118880
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发表时间：
1996-01-01
影响因子：
2.4
通讯作者：
Jahanshahi, M
中科院分区：
文献类型：
--
作者：
Brown, RG;Jahanshahi, M
帕金森氏病(PD)患者表现出广泛的认知和运动功能障碍。试图将这些缺陷纳入神经解剖学框架的尝试往往强调它们的独立性。然而，本文件基于行动的概念--有目的的目标导向行为--采取了更广泛的视角，旨在将各种缺陷整合到一个共同的框架中。在帕金森病的运动症状中，运动障碍被选为代表分布式动作控制系统的崩溃。失动症的三个方面被认为是启动动作的迟缓、执行动作的迟缓和自发运动的贫乏。所有这些都被视为该系统试图在认知、运动和综合水平上应对或适应疾病过程施加的限制的表面表现。
Patients with Parkinson's disease (PD) present with a wide range of cognitive and motor dysfunctions. Attempts to fit these deficits into a neuroanatomical framework have tended to emphasise their separateness. This paper, however, takes a broader perspective based on the concept of action - purposeful goal-directed behaviour - which serves to integrate the various deficits into a common framework. Of the motor symptoms of PD, akinesia is chosen as representing a breakdown in a distributed system of action control. Three aspects of akinesia are considered - slowness to initiate movement, slowness to execute movement and poverty of spontaneous movement. All are seen as being surface manifestation of the system's attempts to cope with or adapt to the limitations imposed by the disease process, at a cognitive, motor and integrative level.