Corticobasal syndrome with visual hallucinations and probable REM-sleep behavior disorder: an autopsied case report of a patient with CBD and LBD pathology.
Corticobasal syndrome with visual hallucinations and probable REM-sleep behavior disorder: an autopsied case report of a patient with CBD and LBD pathology.
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皮质基底节综合征伴视幻觉和可能的快速眼动睡眠行为障碍：一名患有 CBD 和 LBD 病理学的患者的尸检病例报告。
DOI：
10.1080/13554794.2019.1604973
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发表时间：
2019
期刊：
影响因子：
0.8
通讯作者：
Seeley,WilliamW
中科院分区：
文献类型：
--
作者：
Naasan,George;Shany-Ur,Tal;Sidhu,Manu;Barton,Cynthia;Ketelle,Robin;Shdo,SuzanneM;Kramer,JoelH;Miller,BruceL;Seeley,WilliamW
皮质基底综合征和路易体痴呆是具有独特和重叠特征的临床表现，但病理基础不同。我们报告一例80岁男性患者，表现为失用症、僵硬、行动迟缓、右臂肌挛，可能有10年的快速眼动睡眠行为障碍史，后来出现视觉幻觉。尸检时，他的病理特征为皮质基底变性，路易体病局限于脑干。本报告强调了当临床表现不符合分类时考虑共存病理的重要性，并证明路易体痴呆的显著特征可能是由仅限于脑干的病理引起的。
Corticobasal syndrome and dementia with Lewy bodies are clinical presentations with unique and overlapping features but distinct pathological substrates. We report the case of an 80 year-old man who presented with apraxia, rigidity, slowness, right arm myoclonus, a 10-year history of probable REM-sleep behavior disorder, and later developed visual hallucinations. At autopsy, he had pathological features of corticobasal degeneration, and Lewy body disease confined to the brainstem. This report highlights the importance of considering co-existing pathologies when a clinical presentation defies categorization, and demonstrates that salient features of dementia with Lewy bodies may result from pathology limited to the brainstem.