Spice: A never ending story?
Spice: A never ending story?
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DOI：
10.1016/j.forsciint.2009.06.008
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发表时间：
2009-10-30
影响因子：
2.2
通讯作者：
Beuerle, Till
中科院分区：
文献类型：
--
作者：
Lindigkeit, Rainer;Boehme, Anja;Beuerle, Till
2009年1月22日，德国卫生当局禁止了几种非传统的大麻素，这些大麻素被证明是流行的“生物设计师药物”（如“香料”和类似产品）的活性成分。最近在欧洲和日本发现的CP 47，497-C8证明这些产品已经在世界范围内传播。我们合成了几种潜在的有意义的烷基氨基吲哚（烷基链C-3至C-7），并从“Spice Gold”中分离出CP 47，497-C8。对化合物进行了纯化，并通过NMR和质谱法进行了表征。借助这些真实的参考文献，我们能够检测和量化不同草药混合物中添加的精神活性化合物。在2008年12月禁令生效前采集的所有样品都含有CP 47，497-C8（5.4-11.0 mg/g）或JWH-018（2.3 mg/g）。2009年3月，即禁令实施4周后，采集的一些样品仍含有CP 47，497-C8（3.0-3.3 mg/g），但不再检测到JWH-018。相反，它被其非调节C-4同系物JWH-073（5.8-22.9 mg/g）取代。此外，一些新产品不含任何非传统大麻素。据我们所知，这是JWH-073作为新设计药物出现的第一份报告。本文提供的数据和方法将有助于并加速复杂基质中这些化合物的检测。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
On January 22nd 2009, the German Health Authorities prohibited several non-traditional cannabinoids, that proved to be the active components in popular "Bio-Designer-Drugs" like "Spice" and analogous products. The recent detection of CP 47,497-C8 in Europe and Japan documents that these products have already spread world wide. We synthesized several potentially interesting alkylaminoindoles (alkylchain C-3 to C-7) and isolated CP 47,497-C8 from "Spice Gold". The compounds were purified and characterized by NMR and mass spectrometry methods. With the aid of these authentic references we were able to detect and quantify added psychoactive compounds in different herbal blends. All samples that were acquired before the prohibition in December 2008 contained either CP 47,497-C8 (5.4-11.0 mg/g) or JWH-01 8 (2.3 mg/g). Some samples acquired in March 2009, 4 weeks after the prohibition took place, still contained CP 47,497-C8 (3.0-3.3 mg/g) but JWH-018 was not detected anymore. Instead it was replaced by its non-regulated C-4-homolog JWH-073 (5.8-22.9 mg/g). Furthermore some of the new products did not contain any non-traditional cannabinoids. To our knowledge this is the first report of the appearance JWH-073 as a new designer drug. The data and method presented here will facilitate and accelerate the detection of these compounds in complex matrices. (C) 2009 Elsevier Ireland Ltd. All rights reserved.