Potential of electron transfer and its application in dictating routes of biochemical processes associated with metabolic reprogramming.
Potential of electron transfer and its application in dictating routes of biochemical processes associated with metabolic reprogramming.
复制标题
电子转移的潜力及其在决定与代谢重编程相关的生化过程途径中的应用。
DOI：
10.1007/s11684-021-0866-1
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Li Binghui
中科院分区：
文献类型：
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作者：
Yang Ronghui;Ying Guoguang;Li Binghui
代谢重编程，如葡萄糖的异常利用、对谷氨酰胺的上瘾和去诺和脂合成的增加，广泛存在于增殖期的癌细胞中，但其背后的机制仍有待阐明。基于化合物还原程度的概念，我们最近提出了一种称为电子转移势(PET)的计算方法，用于表征电子再分布与代谢转化的程度。当这一计算与细胞环境中电子平衡的假设模型相结合时，可以通过检查与无氧代谢中的生化途径相关的PET值的净变化来预测强制的选择性重新编程。还讨论了癌细胞中PET的一些有趣的性质，并对该模型进行了扩展，以揭示有氧糖酵解的化学本质，其本质是能量需求和电子平衡的结果。启用电子转移可以推动癌症新陈代谢中的代谢重新编程。因此，建立的电子转移的概念和模型可以指导肿瘤的治疗策略和未来的细胞代谢研究。
Metabolic reprogramming, such as abnormal utilization of glucose, addiction to glutamine, and increasedde-novolipid synthesis, extensively occurs in proliferating cancer cells, but the underneath rationale has remained to be elucidated. Based on the concept of the degree of reduction of a compound, we have recently proposed a calculation termed as potential of electron transfer (PET), which is used to characterize the degree of electron redistribution coupled with metabolic transformations. When this calculation is combined with the assumed model of electron balance in a cellular context, the enforced selective reprogramming could be predicted by examining the net changes of the PET values associated with the biochemical pathways in anaerobic metabolism. Some interesting properties of PET in cancer cells were also discussed, and the model was extended to uncover the chemical nature underlying aerobic glycolysis that essentially results from energy requirement and electron balance. Enabling electron transfer could drive metabolic reprogramming in cancer metabolism. Therefore, the concept and model established on electron transfer could guide the treatment strategies of tumors and future studies on cellular metabolism.