BEHAVIOR OF CERTAIN PYRIDINES, QUINOLINES, AND ISOQUINOLINES WITH AMINO OR HYDRAZINO SUBSTITUENTS TOWARD N-ACYLAMINO ACIDS UNDER THE INFLUENCE OF PAPAIN CATALYSIS
BEHAVIOR OF CERTAIN PYRIDINES, QUINOLINES, AND ISOQUINOLINES WITH AMINO OR HYDRAZINO SUBSTITUENTS TOWARD N-ACYLAMINO ACIDS UNDER THE INFLUENCE OF PAPAIN CATALYSIS
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DOI：
10.1021/jo01081a025
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发表时间：
1960-01-01
影响因子：
3.6
通讯作者：
KILDAY, W
中科院分区：
文献类型：
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作者：
ABERNETHY, JL;KILDAY, W
3-已发现氨基喹啉和3-肼基喹啉与马尿酸、苄氧羰基甘氨酸和苄氧羰基-L-丙氨酸反应形成酰胺样产物。在木瓜蛋白酶催化下，它们都能有效地拆分苄氧羰基-DL-丙氨酸和苯甲酰基-DL-丙氨酸。然而，当单独使用苯甲酰基-L-丙氨酸时，两种含氨基的碱基都不与该单一对映体发生木瓜蛋白酶催化的反应。在木瓜蛋白酶催化下，许多氨基吡啶、氨基喹啉、4-氨基异喹啉和2-肼基喹啉不能与这组相同的N-酰基氨基甲酸反应。
3-Aminoquinoline and 3-hydrazinoquinoline havebeen found to undergo reactions with hippuric acid, carbobenzoxyglycine, and carbobenzoxy-L-alanine in the formation of amide-like products. Also, they both effectively resolve carbo-benzoxy-DL-alanine and benzoyl-DL-alanine under papain catalysis. When benzoyl-L-alanine is used alone, however, neither of the amino-containing bases undergoes a papain-catalyzed reaction with this single antipode. A number of aminopyridines, aminoquinolines, 4-aminoisoquinoline, and 2-hydrazinoquinoline failed to react, under papain catalysis, with this same selected group ofN-acy laminoacids.