Antibody responses to honey-bee venom and monomethoxy-polyethylene glycol-modified honey-bee venom in mice.
Antibody responses to honey-bee venom and monomethoxy-polyethylene glycol-modified honey-bee venom in mice.
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小鼠对蜜蜂毒液和单甲氧基聚乙二醇修饰的蜜蜂毒液的抗体反应。
DOI：
10.1159/000233395
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
E. Åkerblom
中科院分区：
文献类型：
--
作者：
S. Ahlstedt;B. Björkstén;E. Åkerblom
用明胶或无佐剂每日注射蜂毒(乙肝病毒)的小鼠产生了IgE同型抗体反应。致敏小鼠单次注射单甲氧基聚乙二醇修饰的乙肝病毒。通过用修饰的而不是天然的乙肝病毒进行这种处理，实现了对IgE抗体反应的抑制。相比之下，免疫球蛋白抗体反应不变或增强。
Antibody responses of the IgE isotype were raised in mice with honey-bee venom (HBV) administered in alum or by daily injections without adjuvant. The sensitized mice were treated with single injections of HBV modified with monomethoxy-polyethylene glycol. By such treatment with modified but not with natural HBV, suppression of the IgE antibody responses was achieved. The IgG antibody responses, in contrast, were unchanged or enhanced.