What does cue-reactivity have to offer clinical research?
What does cue-reactivity have to offer clinical research?
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DOI：
10.1046/j.1360-0443.95.8s2.2.x
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发表时间：
2000-08-01
期刊：
影响因子：
6
通讯作者：
Drummond, DC
中科院分区：
文献类型：
--
作者：
Drummond, DC
本文探讨应用线索反应范式作为研究酒精依赖在临床人群中的一种手段。三个主要的应用领域将被检查：线索反应性作为一种手段，了解酒精依赖的性质;线索反应性作为复发的预测;和线索反应性作为一种方法，研究治疗效果。线索暴露和线索反应性的研究有着悠久的历史，但线索反应性作为理解和治疗成瘾行为的一种手段的潜力只是最近才得到深入研究。线索反应性研究成瘾行为的主要优势在于它在广泛研究的一般行为理论中有着坚实的基础。线索反应性也提供了一种测量和解开渴望概念的方法。渴望一直被认为是成瘾行为的基础，在大多数研究中，渴望被概念化，并以相对简单的方式测量。渴望通常被视为一种单一的现象，并使用自我报告的问卷进行测量。这些方法的解释价值有限，特别是在最近的精神药理学研究中。显然需要开发新的范例来研究旨在减少饮酒行为的药理学药剂的作用。正是在这一领域，线索反应性目前提供了最大的潜力。特别是，线索反应性范式在线索介导的渴望和戒断渴望之间做出了重要的区分。这可以被视为类似于广泛性焦虑和恐惧刺激引起的焦虑之间的区别。然而，虽然现在对线索反应性的现象有很多了解，但有几个方面需要进一步阐明和研究投资。
This paper examines the application of the cue-reactivity paradigm as a means of studying alcohol dependence in clinical populations. Three main areas of application will be examined: cue-reactivity as a means of understanding the nature of alcohol dependence; cue-reactivity as a predictor of relapse; and cue-reactivity as a method of studying treatment effects. The study of cue exposure and cue-reactivity has a long history but it is only relatively recently that the potential of cue-reactivity as a means of understanding and treating addictive behaviours has been studied in depth. The principal advantage of cue-reactivity over other existing paradigms to study addictive behaviour is in having a solid basis in widely studied general theories of behaviour. Cue-reactivity also provides a means of measuring and unpacking the concept of craving. Craving has long been believed to represent the underlying basis for addictive behaviour, and in the majority of research studies craving has been conceptualized and measured in relatively simplistic ways. Craving has generally been viewed as a unitary phenomenon and measured using self-reported questionnaires. Such approaches have had limited explanatory value, particularly in recent psychopharmacology research. There is clearly a need to develop new paradigms to study the effects of pharmacological agents aimed at attenuating drinking behaviour. It is in this area that cue-reactivity currently offers the greatest potential. In particular, the cue-reactivity paradigm draws an important distinction between cue mediated craving and withdrawal craving. This can be viewed as similar to the distinction between generalised anxiety and anxiety provoked by phobic stimuli. However, while much is now known about the phenomenon of cue-reactivity, several aspects require further elucidation and research investment.