Regulation of Runx2 by post-translational modifications in osteoblast differentiation
Regulation of Runx2 by post-translational modifications in osteoblast differentiation
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DOI：
10.1016/j.lfs.2020.117389
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发表时间：
2020-03-15
期刊：
影响因子：
6.1
通讯作者：
Selvamurugan, N.
中科院分区：
文献类型：
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作者：
Gomathi, K.;Akshaya, N.;Selvamurugan, N.
骨生成是新骨形成的过程，其中转录因子在控制细胞增殖和分化中起重要作用。Runx 2是一种重要的转录因子，它调控间充质干细胞向成骨细胞的分化，成骨细胞进一步成熟为骨细胞。Runx 2作为一种调节剂，可以刺激或抑制成骨细胞的分化。该基因表达/活性的缺陷/改变可能导致骨骼发育不良。因此，Runx 2是研究骨和骨相关疾病的最佳治疗模型基因。在这篇综述中，我们简要概述了Runx 2及其活性的调节，在翻译后水平的磷酸化，乙酰化和泛素化的优点，在控制骨稳态。
Osteogenesis is the process of new bone formation where transcription factors play an important role in controlling cell proliferation and differentiation. Runt-related transcription factor 2 (Runx2), a key transcription factor, regulates the differentiation of mesenchymal stem cells into osteoblasts, which further mature into osteocytes. Runx2 acts as a modulator such that it can either stimulate or inhibit the osteoblast differentiation. A defect/alteration in the expression/activity of this gene may lead to skeletal dysplasia. Runx2 thus serves as the best therapeutic model gene for studying bone and bone-related diseases. In this review, we briefly outline the regulation of Runx2 and its activity at the post-translational levels by the virtue of phosphorylation, acetylation, and ubiquitination in controlling the bone homeostasis.