Osteoinductive porous titanium implants: Effect of sodium removal by dilute HCl treatment
Osteoinductive porous titanium implants: Effect of sodium removal by dilute HCl treatment
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DOI：
10.1016/j.biomaterials.2005.12.014
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发表时间：
2006-05-01
期刊：
影响因子：
14
通讯作者：
Nakamura, T
中科院分区：
文献类型：
--
作者：
Takemoto, M;Fujibayashi, S;Nakamura, T
在之前的研究中，我们观察到经过化学和热处理的等离子喷涂多孔钛具有内在的成骨活性，12个月后Beagle狗的肌肉中会出现骨形成。本研究的目的是优化表面处理，提高骨诱导活性。以前的研究报道，钠的去除将碱处理钛板表面的钛酸钠层转化为更具生物活性的二氧化钛层。在这项研究中，我们开发了一种稀盐酸(HCl)处理多孔钛的方法，它比传统的热水处理更有效地从复杂形状的多孔结构中去除钠。采用了三种类型的表面处理：(A)碱和热处理(AH处理)；(B)碱、热水和热处理(Water-AH处理)；以及(C)碱、稀HCl、热水和热处理(HCl-AH处理)。分别在3、6、12个月时检测植入成年比格犬背部肌肉内的材料的成骨诱导活性。经HCl-AH处理的多孔生物活性钛种植体具有最高的骨诱导性，在3个月内诱导大量骨形成。稀盐酸处理被认为对钛表面既有化学作用(二氧化钛的形成和钠的去除)，也有表面(蚀刻)作用，尽管我们不能确定哪一种是主要因素。然而，在常规的化学和热处理的基础上增加稀盐酸处理是多孔钛植入物的高级表面处理的一个有前途的候选方案。(C)2006爱思唯尔有限公司。保留所有权利。
In a previous study, we observed that chemically and thermally treated plasma-sprayed porous titanium possesses intrinsic osteoinductivity and that bone formation occurs after 12 months in the muscles of beagle dogs. The aim of this study was to optimize the surface treatment and to accelerate the osteoinductivity. Previous studies have reported that sodium removal converts the sodium titanate layer on the surface of an alkali-treated titanium plate into a more bioactive titania layer. In this study, we developed a dilute hydrochloric acid (HCl) treatment for porous titanium, which removed sodium from the complexly shaped porous structure more effectively than conventional hot water treatment. Three types of surface treatments were applied: (a) alkali and heat treatment (AH treatment); (b) alkali, hot water, and heat treatment (Water-AH treatment); and (c) alkali, dilute HCl, hot water, and heat treatment (HCl-AH treatment). The osteoinductivity of the materials implanted in the back muscles of adult beagle dogs was examined at 3, 6, and 12 months. The HCl-AH-treated porous bioactive titanium implant had the highest osteoinductivity, with induction of a large amount of bone formation within 3 months. The dilute HCl treatment was considered to give both chemical (titania formation and sodium removal) and topographic (etching) effects on the titanium surface, although we cannot determine which is the predominant factor. Nevertheless, adding the dilute HCl treatment to the conventional chemical and thermal treatments is a promising candidate for advanced surface treatment of porous titanium implants. (c) 2006 Elsevier Ltd. All rights reserved.