Nature of the liver volume depending on the gender and age assessing volumetry from a reconstruction of the computed tomography.
Nature of the liver volume depending on the gender and age assessing volumetry from a reconstruction of the computed tomography.
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DOI：
10.1371/journal.pone.0261094
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Mizuguchi T
中科院分区：
文献类型：
--
作者：
Harada K;Ishinuki T;Ohashi Y;Tanaka T;Chiba A;Numasawa K;Imai T;Hayasaka S;Tsugiki T;Miyanishi K;Nagayama M;Takemasa I;Kato J;Mizuguchi T
虽然肝脏是一个再生器官，但肝脏体积（LV）的过度损失可导致致命的肝功能衰竭。目前尚不清楚LV是否与年龄相关;然而，已知肝功能随年龄而下降。此外，LV的性别相关作用仍不清楚。本研究旨在研究不同年龄和性别的LV变化。在2018年1月至12月期间，入组了374例接受腹部多排计算机断层扫描（MDCT）进行任何腹部检查的连续患者。使用MDCT评价LV。研究了LV与体重指数（BMI）、体表面积（BSA）、年龄和性别之间的关系。改良的LV（mLV）通过测量LV × 1.5/BSA的公式计算。在我们的研究中，无论是男性（R：0.559 vs. 0.416）还是女性（R：0.479 vs. 0.300），LV与BSA的相关性均大于与BMI的相关性。年龄与LV和BSA呈负相关，并且在男性（R：0.546 vs. 0.393）和女性（R：0.506 vs. 0.385）中与LV的相关性大于BSA。此外，男性年龄与LV之间的绝对斜率高于女性（分别为14.1 vs. 10.2）。此外，雄性动物的年龄和mLV的绝对斜率略高于雌性动物（分别为9.1 vs. 7.3）。总之，LV在正常的肝脏是相关的年龄，而不是在患病的肝脏。雄性动物的肝脏体积随年龄的下降幅度大于雌性动物的LV。
Although the liver is a regenerating organ, excessive loss of liver volume (LV) can cause fatal liver failure. It is unclear whether LV is correlated with age; however, it is known that liver function decreases with age. In addition, the gender-related role of LV remains unclear. This study aimed to investigate the changes in LV by age and gender. Between January and December 2018, 374 consecutive patients who underwent abdominal multidetector computed tomography (MDCT) for any abdominal examinations were enrolled. LV was evaluated using MDCT. The relationship between the LV and body mass index (BMI), body surface area (BSA), age, and gender was investigated. The modified LV (mLV) was calculated by a formula measured LV × 1.5/BSA. LV correlated to BSA more than to BMI in both the males (R: 0.559 vs. 0.416) and females (R: 0.479 vs. 0.300) in our study. Age was negatively correlated to LV and BSA, and correlated to LV more than to BSA in males (R: 0.546 vs. 0.393) and females (R: 0.506 vs. 0.385). In addition, the absolute slope between age and LV in the males was higher than that in the females (14.1 vs. 10.2, respectively). Furthermore, the absolute slope of age and mLV in the males was slightly higher than in the females (9.1 vs. 7.3, respectively). In conclusion, LV in the normal liver is correlated to age rather than the one in the diseased liver. Liver volume in the males decreased more with age than LV in the females.
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影响因子：
--
作者：
Du Bois, D;Du Bois, EF
通讯作者：
Du Bois, EF
影响因子：
13.5
作者：
Fausto, N;Campbell, JS;Riehle, KJ
通讯作者：
Riehle, KJ
影响因子：
3.2
作者：
Shoup, M;Gonen, M;Fong, YM
通讯作者：
Fong, YM
影响因子：
3.8
作者：
Ribeiro, H. S. C.;Costa, W. L., Jr.;Coimbra, F. J. F.
通讯作者：
Coimbra, F. J. F.
影响因子：
3.2
作者：
Inoue, Yoshihiro;Fujii, Kensuke;Uchiyama, Kazuhisa
通讯作者：
Uchiyama, Kazuhisa