S100P is a novel marker to identify intraductal papillary mucinous neoplasms
S100P is a novel marker to identify intraductal papillary mucinous neoplasms
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DOI：
10.1016/j.humpath.2009.11.007
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发表时间：
2010-06-01
期刊：
影响因子：
3.3
通讯作者：
Tsuneyoshi, Masazumi
中科院分区：
文献类型：
--
作者：
Nakata, Kohei;Nagai, Eishi;Tsuneyoshi, Masazumi
胰腺导管内乳头状黏液性肿瘤根据形态学特征进行亚分类，不同的免疫组化特征与亚型相关。我们以前报道，S100 P是胰腺癌发生的早期发育标志物，并且在导管内乳头状粘液性肿瘤中的S100 P表达高于正常胰腺导管上皮。然而，目前还没有新的诊断标记物来区分导管内乳头状粘液性肿瘤和非肿瘤性病变的报道。应用免疫组化方法对105例乳腺导管内乳头状黏液性肿瘤进行了研究。S100 P在正常胰腺导管上皮中未检测到表达，但在所有导管内乳头状粘液性肿瘤细胞（100%）中检测到弥漫性核染色或核/胞质染色。MUC 5AC也在大多数导管内乳头状粘液性肿瘤中表达（102/105; 97%）。此外，S100 P在导管内乳头状黏液性肿瘤的浸润性部分（32/32; 100%）中明确表达，包括神经周和淋巴管以及微小浸润。另一方面，MUC 5AC在32种侵袭性成分中仅23例表达（P < .01）。这些数据表明，S100 P抗体可能是一个有用的标记物，用于检测所有类型的导管内乳头状粘液性肿瘤。(C)2010年爱思唯尔公司All rights reserved.
Intraductal papillary mucinous neoplasms of the pancreas are subclassified based on morphological features, and different immunohistochemical profiles have been identified in association with the subtypes. We previously reported that S100P was an early developmental marker of pancreatic carcinogenesis and that there was higher S100P expression in intraductal papillary mucinous neoplasms than in normal pancreatic ductal epithelium. However, there have been no reports on novel diagnostic markers to distinguish intraductal papillary mucinous neoplasm from nonneoplastic lesions. Surgical specimens of intraductal papillary mucinous neoplasm obtained from 105 patients were investigated using immunohistochemistry. S100P expression was not detected in normal pancreatic ductal epithelium but was detected in all intraductal papillary mucinous neoplasm cells (100%) with diffuse nuclear or nuclear/cytoplasmic staining. MUC5AC was also expressed in most of the intraductal papillary mucinous neoplasms (102/105; 97%). Furthermore, S100P was clearly expressed in the invasive component of intraductal papillary mucinous neoplasms (32/32; 100%), including perineural and lymphatic and minimal invasion. On the other hand, MUC5AC was expressed in only 23 cases of 32 invasive components (P < .01). These data suggest that the S100P antibody may be a useful marker for detecting all types of intraductal papillary mucinous neoplasms. (C) 2010 Elsevier Inc. All rights reserved.