ROX index as predictor of high flow nasal cannula therapy success in acute respiratory failure due to SARS-CoV-2.
ROX index as predictor of high flow nasal cannula therapy success in acute respiratory failure due to SARS-CoV-2.
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DOI：
10.1016/j.rmed.2021.106638
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发表时间：
2021-11
影响因子：
4.3
通讯作者：
Signes-Costa J
中科院分区：
文献类型：
--
作者：
Ferrer S;Sancho J;Bocigas I;Bures E;Mora H;Monclou E;Mulet A;Quezada A;Royo P;Signes-Costa J
高流量鼻插管（HFNC）治疗是急性呼吸衰竭（ARF）患者的有效治疗方法。ROX指数（脉搏血氧饱和度/吸入氧分数与呼吸频率的比值）已被评估用于预测肺炎患者HFNC的成功率。本研究的目的是确定ROX指数是否可以预测SARS-CoV-2肺炎所致ARF患者的HFNC治疗成功。进行了一项观察性、前瞻性研究，纳入了符合HFNC治疗开始标准的继发于SARS-CoV-2肺炎的ARF患者。收集人口统计学、影像学、实验室和临床病程数据。分别于HFNC开始后1 h、6 h、12 h和24 h计算ROX指数。共纳入85例患者（年龄，64.51 ± 11.78岁;男性，69.4%）。47例（55.3%）HFNC失败，其中45例（97.8%）最初采用无创通气（NIV）进行管理。24 h时的ROX指数是HFNC成功的最佳预测因子（AUC 0.826，95%CI 0.593-1.00，p = 0.015），截止点为5.35（S 0.91，Sp 0.79，PPV 0.92，NPP 0.79）。在多因素Logistic回归分析中，24 h ROX指数被证明是HFNC成功的最佳预测因子。24小时ROX指数（临界点为5.35）可预测SARS-Cov-2诱导的ARF患者HFNC成功。
High-Flow Nasal Cannula (HFNC) therapy is useful treatment in patients with acute respiratory failure (ARF). The ROX index (ratio of pulse oximetry/fraction of inspired oxygen to respiratory rate) has been evaluated to predict success of HFNC in patients with pneumonia. The aim of this study was to determine whether the ROX Index could predict HFNC therapy success in patients with ARF due to SARS-CoV-2 pneumonia. An observational, prospective study was performed including patients admitted with ARF secondary to SARS-CoV-2 pneumonia who met criteria for HFNC therapy initiation. Demographic, radiological, laboratory and clinical course data were collected. The ROX index was calculated at 1 h, 6 h, 12 h and 24 h after starting HFNC. In total 85 patients were included (age, 64.51 + 11.78 years; male, 69.4%). HFNC failed in 47 (55.3%) patients, of whom 45 (97.8%) were initially managed with noninvasive ventilation (NIV). ROX index at 24 h was the best predictor of HFNC success (AUC 0.826, 95%CI 0.593–1.00, p = 0.015) with a cut-off point of 5.35 (S 0.91, Sp 0.79, PPV 0.92, NPP 0.79). In multivariate logistic regression analysis ROX index at 24 h proved the best predictor of HFNC success. ROX index at 24 h with a cut-off point of 5.35 predicts HFNC success in patients with SARS-Cov-2-induced ARF.
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影响因子：
2.3
作者：
Panadero C;Abad-Fernández A;Rio-Ramirez MT;Acosta Gutierrez CM;Calderon-Alcala M;Lopez-Riolobos C;Matesanz-Lopez C;Garcia-Prieto F;Diaz-Garcia JM;Raboso-Moreno B;Vasquez-Gambasica Z;Andres-Ruzafa P;Garcia-Satue JL;Calero-Pardo S;Sagastizabal B;Bautista D;Campos A;González M;Grande L;Jimenez Fernandez M;Santiago-Ruiz JL;Caravaca Perez P;Alcaraz AJ
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影响因子：
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DOI：
10.15557/pimr.2020.0003
发表时间：
2020-01-01
影响因子：
3.6
作者：
通讯作者：
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影响因子：
2.5
作者：
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通讯作者：
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