Neodymium-doped NaHoF4 nanoparticles as near-infrared luminescent/T2-weighted MR dual-modal imaging agents in vivo
Neodymium-doped NaHoF4 nanoparticles as near-infrared luminescent/T2-weighted MR dual-modal imaging agents in vivo
复制标题
掺钕 NaHoF4 纳米颗粒作为体内近红外发光/T2 加权 MR 双模态成像剂
DOI：
10.1039/c6tb01961g
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发表时间：
2017-01-21
影响因子：
7
通讯作者：
Lin, Hongzhen
中科院分区：
文献类型：
--
作者：
Feng, Yamin;Xiao, Qingbo;Lin, Hongzhen
The achievement of efficient near-infrared (NIR) luminescence of lanthanide ions in a paramagnetic nanoparticle (NP) host is highly desirable to optimize the performance of multimodal bioprobes. Herein, we present a facile coprecipitation method to prepare highly uniform NaHoF4: Nd3+ nanoplates. Upon NIR excitation at 785 nm, efficient NIR luminescence of Nd3+ can be obtained from the paramagnetic NaHoF4 hosts. More interestingly, due to energy transfer from the excited state of Nd3+ to the adjacent Ho3+, NIR emission at around 1200 nm from Ho3+ ions is also observed. The r(2) value of NaHoF4: Nd3+ NPs reaches 143.7 s(-1) mM(-1) at a high magnetic field of 11.7 T. By modifying with hydrophilic alpha-cyclodextrin, the NaHoF4: Nd3+ NPs were further successfully applied for the NIR luminescent/T-2-weighted MR dual-modal in vivo imaging of nude mice, high contrast NIR imaging of the liver and T-2-weighted MR imaging of stem cells in the mouse brain using the NaHoF4: Nd3+ NPs as multimodal bioprobes.
