Brain structure and internalizing and externalizing behavior in typically developing children and adolescents
Brain structure and internalizing and externalizing behavior in typically developing children and adolescents
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DOI：
10.1007/s00429-019-01973-y
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发表时间：
2019-11-07
影响因子：
3.1
通讯作者：
Lebel, Catherine
中科院分区：
文献类型：
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作者：
Andre, Quinn R.;Geeraert, Bryce L.;Lebel, Catherine
心理健康问题通常出现在青春期，与前额叶皮质(PFC)和边缘系统中灰质厚度或体积的减少以及连接这些区域的白质的部分各向异性(FA)和平均扩散率(MD)的减少有关。然而，很少有研究调查内化和外化行为是否与没有心理健康障碍的儿童和青少年的大脑结构有关，这对于了解症状的发展是重要的。67个T1加权和扩散张量成像数据集来自48名典型的6-16岁发育中的参与者(37m/30f；19名参与者有两次访问)。计算前额叶和边缘结构的体积，并评估边缘白质的弥散参数。使用线性混合效应模型计算大脑结构与内化和外化行为之间的关联，并使用儿童行为评估系统(BASC-2)父母评定量表进行评估。内化行为与双侧扣带核MD呈正相关。在扣带回发现了性别交互作用，MD与女性内化行为之间存在更强的正相关关系。外化行为与左侧扣带回FA呈负相关，左侧钩束呈年龄-行为交互作用。行为和脑体积之间的关系没有在多次比较校正中幸存下来。这些结果表明，边缘白质FA和MD的改变与亚临床的内化和外化行为有关，并加深了我们对神经标记物的理解，这些标记物可能是未来精神健康障碍的潜在风险。
Mental health problems often emerge in adolescence and are associated with reduced gray matter thickness or volume in the prefrontal cortex (PFC) and limbic system and reduced fractional anisotropy (FA) and increased mean diffusivity (MD) of white matter linking these regions. However, few studies have investigated whether internalizing and externalizing behavior are associated with brain structure in children and adolescents without mental health disorders, which is important for understanding the progression of symptoms. 67 T1-weighted and diffusion tensor imaging datasets were obtained from 48 typically developing participants aged 6-16 years (37M/30F; 19 participants had two visits). Volume was calculated in the prefrontal and limbic structures, and diffusion parameters were assessed in limbic white matter. Linear mixed effects models were used to compute associations between brain structure and internalizing and externalizing behavior, assessed using the Behavioral Assessment System for Children (BASC-2) Parent Rating Scale. Internalizing behavior was positively associated with MD of the bilateral cingulum. Gender interactions were found in the cingulum, with stronger positive relationships between MD and internalizing behavior in females. Externalizing behavior was negatively associated with FA of the left cingulum, and the left uncinate fasciculus showed an age-behavior interaction. No relationships between behavior and brain volumes survived multiple comparison correction. These results show altered limbic white matter FA and MD related to sub-clinical internalizing and externalizing behavior and further our understanding of neurological markers that may underlie risk for future mental health disorders.