RECENT PRIMARY TOXOPLASMA INFECTION INDICATED BY A LOW AVIDITY OF SPECIFIC IGG
RECENT PRIMARY TOXOPLASMA INFECTION INDICATED BY A LOW AVIDITY OF SPECIFIC IGG
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DOI：
10.1093/infdis/159.4.736
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发表时间：
1989-04-01
影响因子：
6.4
通讯作者：
MAKELA, O
中科院分区：
文献类型：
--
作者：
HEDMAN, K;LAPPALAINEN, M;MAKELA, O
建立了一种新的弓形虫原发感染的血清学诊断方法。该试验测量弓形虫特异性IgG抗体的抗原结合亲合力。5例近期原发性弓形虫感染患者的血清样本与21例既往存在弓形虫免疫的受试者进行了比较。原发性感染的患者表现出低亲和力的弓形虫特异性IgG，持续几个月后，弓形虫病的症状发作。相反，所有受试者与过去的免疫有较高的亲和力的弓形虫IgG。这种IgG抗体亲合力测定应有助于获得性弓形虫病的诊断，并可用于识别有先天性弓形虫病风险的妊娠。
An unusual assay was developed for the serologic diagnosis of recent primary infection by Toxoplasma gondii. This test measures the antigen-binding avidity of toxoplasma-specific IgG antibodies. Serum samples from 5 patients with recent primary toxoplasma infection were compared with those from 21 subjects with preexisting toxoplasma immunity. Patients with primary infection exhibited a low avidity of toxoplasma-specific IgG, which persisted for several months after the onset of symptoms of toxoplasmosis. In contrast, all subjects with past immunity had a high avidity of toxoplasma-IgG. This IgG avidity assay should assist in the diagnosis of acquired toxoplasmosis and may be used to identify pregnancies that are at risk for congenital toxoplasmosis.