The effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors in normal male rats
The effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors in normal male rats
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DOI：
10.1016/j.phymed.2007.09.020
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发表时间：
2008-06-01
期刊：
影响因子：
7.9
通讯作者：
Sadeghi, A.
中科院分区：
文献类型：
--
作者：
Hosseinzadeh, H.;Ziaee, T.;Sadeghi, A.
本文研究了藏红花柱头水提物及其成分藏红花醛和藏红花素对雄性大鼠的壮阳作用。雄性大鼠经腹腔注射水提物（80、160和320mg/kg体重量）、藏红花素（100、200和400mg/kg体重量）、番红花醛（0.1、0.2和0.4ml/kg体重量）、西地那非（60mg/kg体重量，作为阳性对照）和生理盐水。安装频率（MF）、插入频率（IF）、勃起频率（EF）、安装潜伏期（ML）、插入潜伏期（IL）和射精潜伏期（EL）是性行为研究中评估的因素。在所有剂量下，藏红花素和提取物，特别是在160和320 mg/kg体重剂量下，增加了MF、IF和EF行为，降低了EL、IL和ML参数。Safranal没有显示出壮阳作用。本研究揭示了藏红花水提物及其成分藏红花素具有壮阳作用。(c) 2007 Elsevier GrnbH。版权所有。
In this study, the aphrodisiac activities of Crocus sativus stigma aqueous extract and its constituents, safranal and crocin, were evaluated in male rats. The aqueous extract (80, 160 and 320mg/kg body wt.), crocin (100, 200 and 400mg/kg body wt.), safranal (0.1, 0.2 and 0.4ml/kg), sildenafil (60mg/kg body wt., as a positive control) and saline were administered intraperitoneally to male rats. Mounting frequency (MF), intromission frequency (IF), erection frequency (EF), mount latency (ML), intromission latency (IL) and ejaculation latency (EL) were the factors evaluated during the sexual behavior study. Crocin, at all doses, and the extract, especially at doses 160 and 320 mg/kg body wt., increased MF, IF and EF behaviors and reduced EL, IL and ML parameters. Safranal did not show aphrodisiac effects. The present study reveals an aphrodisiac activity of saffron aqueous extract and its constituent crocin. (c) 2007 Elsevier GrnbH. All rights reserved.