Biologic Therapies in Pediatric Asthma
Biologic Therapies in Pediatric Asthma
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DOI：
10.3390/jpm12060999
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发表时间：
2022-06-18
影响因子：
--
通讯作者：
Paraskakis, Emmanouil
中科院分区：
文献类型：
--
作者：
Perikleous, Evanthia P.;Steiropoulos, Paschalis;Nena, Evangelia;Paraskakis, Emmanouil
不可否认，儿童哮喘是一种广泛存在于儿童中的多因素、异质性慢性疾病。其治疗，尤其是对标准治疗难治的严重形式，仍然具有挑战性。在过去的几十年里，生物制剂的开发及其随后的批准提供了一种先进且非常有前途的治疗替代方案，最终指向成功的精准医疗方法。目前批准的儿童严重哮喘附加治疗的应用，即奥马利珠单抗、美泊利珠单抗、贝那利珠单抗、杜匹鲁单抗和特泽佩鲁单抗，已被证明在哮喘控制和恶化率方面是有效的。然而，迄今为止，仍缺乏有关其长期使用的信息。因此，数据经常是从成人研究中推断出来的。因此，合适的生物制剂的选择、良好哮喘反应的潜在预测因素以及儿科人群的长期结果仍有待进一步研究。本研究的目的是概述已出现并应用于哮喘管理领域的所有许可单克隆抗体 (mAb) 的最新证据的现状。还简要讨论了创新的未来目标。
Undeniably, childhood asthma is a multifactorial and heterogeneous chronic condition widespread in children. Its management, especially of the severe form refractory to standard therapy remains challenging. Over the past decades, the development of biologic agents and their subsequent approval has provided an advanced and very promising treatment alternative, eventually directing toward a successful precision medicine approach. The application of currently approved add-on treatments for severe asthma in children, namely omalizumab, mepolizumab, benralizumab, dupilumab, and tezepelumab have been shown to be effective in terms of asthma control and exacerbation rate. However, to date, information is still lacking regarding its long-term use. As a result, data are frequently extrapolated from adult studies. Thus, the selection of the appropriate biologic agent, the potential predictors of good asthma response, and the long-term outcome in the pediatric population are still to be further investigated. The aim of the present study was to provide an overview of the current status of the latest evidence about all licensed monoclonal antibodies (mAbs) that have emerged and been applied to the field of asthma management. The innovative future targets are also briefly discussed.
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影响因子：
3.6
作者：
Conrad LA;Cabana MD;Rastogi D
通讯作者：
Rastogi D
DOI：
10.1016/j.jaip.2018.04.043
发表时间：
2019-01-01
影响因子：
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作者：
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作者：
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影响因子：
158.5
作者：
Bel, Elisabeth H.;Wenzel, Sally E.;Pavord, Ian D.
通讯作者：
Pavord, Ian D.