Training voluntary motor suppression with real-time feedback of motor evoked potentials.

Training voluntary motor suppression with real-time feedback of motor evoked potentials.
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通过运动诱发电位的实时反馈来训练自愿运动抑制。

DOI:
10.1152/jn.00992.2014
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发表时间:
2015
影响因子:
2.5
通讯作者:
Aron,AdamR
Aron,AdamR
中科院分区:
医学3区
文献类型:
--
作者:
Majid,DSAdnan;Lewis,Christina;Aron,AdamR

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训练人们自愿抑制运动表征可以改善反应控制。我们对经颅磁刺激(TMS)产生的运动诱发电位(MEPs)在运动皮层上的实时反馈训练过程进行了评估。在每次试验中,一个提示指示参与者使用一种心理策略来抑制特定的手指表征,而不进行明显的动作。通过运动皮层传递单脉冲TMS,并在500 ms内将mep衍生的手部运动兴奋性测量视觉传递给参与者。在实验1中,我们发现参与者在30分钟的练习中学会了将特定手指的兴奋性降低到基线以下(选择性运动抑制)。在实验2中,我们进行了双盲研究,包括两个训练组(一个具有真实反馈,另一个具有匹配的虚假反馈),以表明选择性运动抑制取决于真实反馈本身。实验3进一步证明了真实反馈的重要性,它表明,即使有奖励激励,选择性运动抑制也不是仅仅由心理意象产生的。因此,被试可以利用tms诱导的MEPs的实时反馈来发现选择性运动抑制的有效心理策略。这种高时间分辨率、一次试验一次反馈的训练方法可以用来帮助人们更好地控制反应倾向,并可能作为一种潜在的治疗运动障碍,如图雷特氏症和肌张力障碍。
Training people to suppress motor representations voluntarily could improve response control. We evaluated a novel training procedure of real-time feedback of motor evoked potentials (MEPs) generated by transcranial magnetic stimulation (TMS) over motor cortex. On each trial, a cue instructed participants to use a mental strategy to suppress a particular finger representation without overt movement. A single pulse of TMS was delivered over motor cortex, and an MEP-derived measure of hand motor excitability was delivered visually to the participant within 500 ms. Inexperiment 1, we showed that participants learned to reduce the excitability of a particular finger beneath baseline (selective motor suppression) within 30 min of practice. Inexperiment 2, we performed a double-blind study with 2 training groups (1 with veridical feedback and 1 with matched sham feedback) to show that selective motor suppression depends on the veridical feedback itself.Experiment 3further demonstrated the importance of veridical feedback by showing that selective motor suppression did not arise from mere mental imagery, even when incentivized with reward. Thus participants can use real-time feedback of TMS-induced MEPs to discover an effective mental strategy for selective motor suppression. This high-temporal-resolution, trial-by-trial-feedback training method could be used to help people better control response tendencies and may serve as a potential therapy for motor disorders such as Tourette's and dystonia.
局灶性手部肌张力障碍的皮质内抑制调节受损。
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