RECOVERY FROM INFANTS WITH RESPIRATORY ILLNESS OF A VIRUS RELATED TO CHIMPANZEE CORYZA AGENT (CCA) .2. EPIDEMIOLOGIC ASPECTS OF INFECTION IN INFANTS AND YOUNG CHILDREN
RECOVERY FROM INFANTS WITH RESPIRATORY ILLNESS OF A VIRUS RELATED TO CHIMPANZEE CORYZA AGENT (CCA) .2. EPIDEMIOLOGIC ASPECTS OF INFECTION IN INFANTS AND YOUNG CHILDREN
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DOI：
10.1093/oxfordjournals.aje.a119902
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发表时间：
1957-01-01
影响因子：
--
通讯作者：
FINBERG, L
中科院分区：
文献类型：
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作者：
CHANOCK, R;FINBERG, L
进行了一项研究，以阐明一种病原体（龙病毒）的流行病学，该病原体从一名患有支气管肺炎的婴儿身上回收，并显示与黑猩猩鼻炎病原体（CCA）无法区分。在婴幼儿感染的血清学诊断中，中和试验的敏感性是补体结合技术的两倍。在本研究人群中，80%的4岁儿童血清中具有Long病毒中和活性。7%的未住院的对照婴儿和儿童，在最初出血时没有明显的呼吸道疾病，在冬季的平均6周内产生了Long病毒抗体。一个类似的对照组中的感染率，谁住院的病房，不承认传染病患者是6倍以上的门诊控制从同一家医院。在住院患者中，Long病毒与严重下呼吸道疾病的相关性无法得到证实，可能是因为病房对照组的感染率较高。这些数据表明，龙病毒和支气管肺炎发生在门诊病人之间的关联。然而，支气管肺炎门诊患者的数量很少（13例），因此从这些数据得出的结论必须被认为是初步的。建议将本研究中分离的病原体和CCA病毒归为一类，并命名为“呼吸道合胞体”（RS）病毒。
A study was carried out to elucidate the epidemiology of an agent (Long virus) which was recovered from an infant with bronchopneumonia and shown to be indistinguishable from chimpanzee coryza agent (CCA). The neutralization test was twice as sensitive as the complement-fixation technique in the serologic diagnosis of infection in infants and small children. In the present study population, 80% of children 4 years of age possessed neutralizing activity for Long virus in their serum. Seven per cent of nonhospitalized control infants and children, without overt respiratory illness at the time of initial bleeding, developed antibody for Long virus during the average interval of 6 weeks in the winter months. The rate of infection among a similar control group who were hospitalized on a ward which did not admit patients with infectious disease was 6 times greater than among the outpatient controls from the same hospital. An association of Long virus with severe lower respiratory illness in hospitalized patients could not be demonstrated, possibly because of the high rate of infection occurring in the ward control group. The data suggested an association between Long virus and bronchopneumonia occurring in outpatients. However, the number of outpatients with bronchopneumonia was small (13 individuals) and thus the conclusions derived from these data must be considered tentative. It is proposed that the agents isolated in this study and the CCA virus be grouped together and named "respiratory syncytial" (RS) virus.