Effect of senescence on macrophage polarization and angiogenesis
Effect of senescence on macrophage polarization and angiogenesis
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DOI：
10.1089/rej.2007.0614
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发表时间：
2008-02-01
影响因子：
2.6
通讯作者：
Apte, Rajendra S.
中科院分区：
文献类型：
--
作者：
Dace, Dru S.;Apte, Rajendra S.
越来越多的证据表明，随着免疫系统的老化，正常功能会逐渐恶化。衰老称为免疫衰老，它影响先天性和适应性免疫反应。这篇综述讨论了先天免疫系统中与年龄相关的变化，特别关注巨噬细胞。改变巨噬细胞功能的异常血管生成的病理生理学与年龄相关的眼病的下游影响也进行了讨论。
There is mounting evidence that as the immune system ages, a progressive deterioration in normal function occurs. Termed immunosenescence, aging impacts both the innate and adaptive immune responses. This review discusses the age-related alterations in the innate immune system, with a specific focus on macrophages. The downstream effect of altered macrophage function on aberrant angiogenesis in the pathophysiology of age-related eye disease is also discussed.